药物输送系统的最新趋势。

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Omnia Mohamed Sarhan
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引用次数: 0

摘要

药物输送系统正在通过整合复杂的纳米技术来提高治疗效果。基于透明质酸的纳米载体在癌症治疗领域取得了巨大的进步,因为它具有将药物精确输送到目标区域的能力。量子点表现出独特的光学特性,允许精确的药物管理和监测能力。碳纳米管提供了一个大的表面积和特殊的强度,允许精确操纵药物输送模式。树状大分子是一种多功能结构,可以同时运输多种药物,而介孔硅功能化纳米颗粒可以精确控制药物的释放速度。聚合物-脂质杂交纳米颗粒协同整合了聚合物的耐久性和脂质的相容性,从而增加了药物在体内的可用性。六方氮化硼纳米片由于其生物相容性和定制给药的潜力而越来越被认为是有利的载体。这些成就表明了药物管理领域正在发生的变化,纳米技术被用于解决诸如受限的生物利用度和意想不到的副作用等问题。这最终提高了药物的有效性并改善了患者的预后。未来的研究将集中于改进这些技术以获得更广泛的治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Trends in Drug Delivery Systems.

Drug delivery systems are now being advanced by integrating sophisticated nanotechnologies to enhance therapeutic efficacy. Tremendous advancement has been achieved in the field of cancer therapy through the utilization of hyaluronic acid-based nanocarriers, which are well-acknowledged for their capacity to transport medication precisely to targeted regions. Quantum dots exhibit unique optical properties that allow for precise drug administration and monitoring capabilities. Carbon nanotubes provide a large surface area and exceptional strength, allowing for precise manipulation of drug delivery patterns. Dendrimers are versatile structures that can transport many drugs simultaneously, whereas mesoporous silica-functionalized nanoparticles allow exact manipulation of the release rate of pharmaceuticals. Polymer-lipid hybrid nanoparticles synergistically integrate the durability of polymers with the compatibility of lipids, hence augmenting the availability of drugs within the body. Hexagonal boron nitride nanosheets are becoming more recognized as favorable carriers due to their biocompatibility and potential for tailored administration. These achievements demonstrate the changes happening in the field of pharmaceutical administration, where nanotechnology is used to tackle issues such as restricted bioavailability and unanticipated adverse effects. This ultimately enhances the effectiveness of medicines and improves patient outcomes. Future investigations will focus on improving these technologies for broader therapeutic applications.

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来源期刊
Assay and drug development technologies
Assay and drug development technologies 医学-生化研究方法
CiteScore
3.60
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts
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