氧化三甲胺(TMAO)治疗腹主动脉瘤的机制及干预策略。

IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiology Pub Date : 2025-05-10 DOI:10.1159/000546190
Dilixiati Abudureheman, Shuake Janaerbieke, Yuhang Song, Shuo Han, Wufuer Yimaer, Huguo Wang
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引用次数: 0

摘要

本文综述了氧化三甲胺(TMAO)在腹主动脉瘤(AAA)中的作用。氧化三甲胺是肠道菌群作用于饮食前体产生的代谢物,与多种心血管疾病有关。在AAA中,TMAO参与了多个过程。它通过促进巨噬细胞极化和增加血管平滑肌细胞的炎症标志物来诱导炎症。它还参与细胞凋亡和细胞外基质重塑。氧化三甲胺与动脉粥样硬化、高血压和糖尿病等危险因素密切相关,并通过多种机制影响其进展,例如在动脉粥样硬化中,氧化三甲胺促进泡沫细胞形成和内皮细胞损伤。TMAO的干预策略包括饮食调整、肠道菌群调节和关键酶的抑制。饮食调整,如地中海饮食可以降低氧化三甲胺水平,益生菌和益生元已显示出调节肠道微生物群影响氧化三甲胺合成的潜力。然而,这些策略有局限性,需要进一步研究。这篇综述为TMAO在AAA中的作用提供了全面的认识,并为未来的研究和临床应用提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanisms and intervention strategies of TMAO (Trimethylamine NOxide) in abdominal aortic aneurysm.

This review comprehensively discusses the role of trimethylamine oxide (TMAO) in abdominal aortic aneurysm (AAA). TMAO, a metabolite produced by gut microbiota acting on dietary precursors, is associated with various cardiovascular diseases. In AAA, TMAO is involved in multiple processes. It induces inflammation by promoting macrophage polarization and increasing inflammatory markers in vascular smooth muscle cells. It also participates in apoptosis and extracellular matrix remodeling. TMAO is closely associated with risk factors such as atherosclerosis, hypertension, and diabetes and affects their progression through multiple mechanisms, such as in atherosclerosis, where it promotes foam cell formation and endothelial cell damage. Intervention strategies for TMAO include dietary modification, gut microbiota regulation, and inhibition of key enzymes. Dietary modifications such as the Mediterranean diet can reduce TMAO levels, and probiotics and prebiotics have shown a potential to modulate gut microbiota to affect TMAO synthesis. However, these strategies have limitations and require further study. This review provides a comprehensive understanding of the role of TMAO in AAA and provides insights for future research and clinical applications.

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来源期刊
Cardiology
Cardiology 医学-心血管系统
CiteScore
3.40
自引率
5.30%
发文量
56
审稿时长
1.5 months
期刊介绍: ''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.
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