{"title":"氧化三甲胺(TMAO)治疗腹主动脉瘤的机制及干预策略。","authors":"Dilixiati Abudureheman, Shuake Janaerbieke, Yuhang Song, Shuo Han, Wufuer Yimaer, Huguo Wang","doi":"10.1159/000546190","DOIUrl":null,"url":null,"abstract":"<p><p>This review comprehensively discusses the role of trimethylamine oxide (TMAO) in abdominal aortic aneurysm (AAA). TMAO, a metabolite produced by gut microbiota acting on dietary precursors, is associated with various cardiovascular diseases. In AAA, TMAO is involved in multiple processes. It induces inflammation by promoting macrophage polarization and increasing inflammatory markers in vascular smooth muscle cells. It also participates in apoptosis and extracellular matrix remodeling. TMAO is closely associated with risk factors such as atherosclerosis, hypertension, and diabetes and affects their progression through multiple mechanisms, such as in atherosclerosis, where it promotes foam cell formation and endothelial cell damage. Intervention strategies for TMAO include dietary modification, gut microbiota regulation, and inhibition of key enzymes. Dietary modifications such as the Mediterranean diet can reduce TMAO levels, and probiotics and prebiotics have shown a potential to modulate gut microbiota to affect TMAO synthesis. However, these strategies have limitations and require further study. This review provides a comprehensive understanding of the role of TMAO in AAA and provides insights for future research and clinical applications.</p>","PeriodicalId":9391,"journal":{"name":"Cardiology","volume":" ","pages":"1-32"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mechanisms and intervention strategies of TMAO (Trimethylamine NOxide) in abdominal aortic aneurysm.\",\"authors\":\"Dilixiati Abudureheman, Shuake Janaerbieke, Yuhang Song, Shuo Han, Wufuer Yimaer, Huguo Wang\",\"doi\":\"10.1159/000546190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This review comprehensively discusses the role of trimethylamine oxide (TMAO) in abdominal aortic aneurysm (AAA). TMAO, a metabolite produced by gut microbiota acting on dietary precursors, is associated with various cardiovascular diseases. In AAA, TMAO is involved in multiple processes. It induces inflammation by promoting macrophage polarization and increasing inflammatory markers in vascular smooth muscle cells. It also participates in apoptosis and extracellular matrix remodeling. TMAO is closely associated with risk factors such as atherosclerosis, hypertension, and diabetes and affects their progression through multiple mechanisms, such as in atherosclerosis, where it promotes foam cell formation and endothelial cell damage. Intervention strategies for TMAO include dietary modification, gut microbiota regulation, and inhibition of key enzymes. Dietary modifications such as the Mediterranean diet can reduce TMAO levels, and probiotics and prebiotics have shown a potential to modulate gut microbiota to affect TMAO synthesis. However, these strategies have limitations and require further study. This review provides a comprehensive understanding of the role of TMAO in AAA and provides insights for future research and clinical applications.</p>\",\"PeriodicalId\":9391,\"journal\":{\"name\":\"Cardiology\",\"volume\":\" \",\"pages\":\"1-32\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-05-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000546190\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546190","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Mechanisms and intervention strategies of TMAO (Trimethylamine NOxide) in abdominal aortic aneurysm.
This review comprehensively discusses the role of trimethylamine oxide (TMAO) in abdominal aortic aneurysm (AAA). TMAO, a metabolite produced by gut microbiota acting on dietary precursors, is associated with various cardiovascular diseases. In AAA, TMAO is involved in multiple processes. It induces inflammation by promoting macrophage polarization and increasing inflammatory markers in vascular smooth muscle cells. It also participates in apoptosis and extracellular matrix remodeling. TMAO is closely associated with risk factors such as atherosclerosis, hypertension, and diabetes and affects their progression through multiple mechanisms, such as in atherosclerosis, where it promotes foam cell formation and endothelial cell damage. Intervention strategies for TMAO include dietary modification, gut microbiota regulation, and inhibition of key enzymes. Dietary modifications such as the Mediterranean diet can reduce TMAO levels, and probiotics and prebiotics have shown a potential to modulate gut microbiota to affect TMAO synthesis. However, these strategies have limitations and require further study. This review provides a comprehensive understanding of the role of TMAO in AAA and provides insights for future research and clinical applications.
期刊介绍:
''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.