T E Kuznetsova, T A Mityukova, A A Basalai, M A Darenskaya, L V Rychkova, S I Kolesnikov, N V Semenova, L I Kolesnikova
{"title":"饮食性内脏性肥胖及饮食矫正后雌雄Wistar大鼠海马组织结构的变化。","authors":"T E Kuznetsova, T A Mityukova, A A Basalai, M A Darenskaya, L V Rychkova, S I Kolesnikov, N V Semenova, L I Kolesnikova","doi":"10.1007/s10517-025-06391-1","DOIUrl":null,"url":null,"abstract":"<p><p>We studied the histological structure of the hippocampus in male and female Wistar rats kept on a standard vivarium diet (StD) or a high-calorie diet (HCD) for 16 weeks. The effect of diet-induced visceral obesity correction was also evaluated. To this end, the rats receiving HCD for 8 weeks were transferred to StD for the next 8 weeks. HCD for 16 weeks led to diet-induced visceral obesity and disturbances in the histological structure of the hippocampus in both males and females. The most typical consequences of HCD were neurodegenerative signs, which appeared in different regions of the hippocampus. Transition to StD was effective not only in correcting visceral obesity, but also in leveling neurodegenerative changes in the structure of hippocampal neurons in male and female rats.</p>","PeriodicalId":9331,"journal":{"name":"Bulletin of Experimental Biology and Medicine","volume":"178 5","pages":"647-653"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Histostructure of the Hippocampus in Male and Female Wistar Rats with Diet-Induced Visceral Obesity and after Diet Correction.\",\"authors\":\"T E Kuznetsova, T A Mityukova, A A Basalai, M A Darenskaya, L V Rychkova, S I Kolesnikov, N V Semenova, L I Kolesnikova\",\"doi\":\"10.1007/s10517-025-06391-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We studied the histological structure of the hippocampus in male and female Wistar rats kept on a standard vivarium diet (StD) or a high-calorie diet (HCD) for 16 weeks. The effect of diet-induced visceral obesity correction was also evaluated. To this end, the rats receiving HCD for 8 weeks were transferred to StD for the next 8 weeks. HCD for 16 weeks led to diet-induced visceral obesity and disturbances in the histological structure of the hippocampus in both males and females. The most typical consequences of HCD were neurodegenerative signs, which appeared in different regions of the hippocampus. Transition to StD was effective not only in correcting visceral obesity, but also in leveling neurodegenerative changes in the structure of hippocampal neurons in male and female rats.</p>\",\"PeriodicalId\":9331,\"journal\":{\"name\":\"Bulletin of Experimental Biology and Medicine\",\"volume\":\"178 5\",\"pages\":\"647-653\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of Experimental Biology and Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10517-025-06391-1\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/29 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of Experimental Biology and Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10517-025-06391-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/29 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Histostructure of the Hippocampus in Male and Female Wistar Rats with Diet-Induced Visceral Obesity and after Diet Correction.
We studied the histological structure of the hippocampus in male and female Wistar rats kept on a standard vivarium diet (StD) or a high-calorie diet (HCD) for 16 weeks. The effect of diet-induced visceral obesity correction was also evaluated. To this end, the rats receiving HCD for 8 weeks were transferred to StD for the next 8 weeks. HCD for 16 weeks led to diet-induced visceral obesity and disturbances in the histological structure of the hippocampus in both males and females. The most typical consequences of HCD were neurodegenerative signs, which appeared in different regions of the hippocampus. Transition to StD was effective not only in correcting visceral obesity, but also in leveling neurodegenerative changes in the structure of hippocampal neurons in male and female rats.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
