乳酸菌上清液对ESKAPE多耐药菌的抑菌作用。

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2025-03-01 Epub Date: 2025-04-28 DOI:10.1007/s10517-025-06385-z

T A Danilova, A A Adzhieva, G A Danilina, A G Minko, O A Dmitrenko, V G Zhukhovitsky

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引用次数: 0

摘要

乳酸菌上清液对ESKAPE组细菌的许多细菌表现出明显的抗菌活性。在聚苯乙烯板上用肉汤微量稀释法测定上清液的抑菌活性。观察到对革兰氏阳性金黄色葡萄球菌的最高抑制水平（与对照相比超过10倍）。在革兰氏阴性菌中，铜绿假单胞菌的抑制水平最高（为对照的9.4倍），鲍曼假单胞菌和肺炎克雷伯菌的抑制水平略低。上清液也抑制革兰氏阳性和革兰氏阴性细菌形成的生物膜。

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Antimicrobial Effect of Lactobacillus Supernatant on Polyresistant Bacteria of the ESKAPE Group.

Lactobacillus supernatants exhibit pronounced antimicrobial activity against a number of bacteria of bacteria of the ESKAPE group. The antimicrobial activity of the supernatant was evaluated using the broth microdilution assay on polystyrene plates. The highest level of inhibition (more than 10 times compared with the control) was observed against gram-positive S. aureus. Among gram-negative bacteria, the maximum level of inhibition (9.4 times compared with the control) was noted for P. aeruginosa and slightly lower in A. baumannii and K. pneumoniae. The supernatants also inhibited biofilm formation by both gram-positive and gram-negative bacteria.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.