{"title":"未被识别的慢性髓性白血病在增殖性糖尿病视网膜病变中表现为出血性并发症:1例报告。","authors":"Shreeya Hinge, Shivraj Tagare, Manavi D Sindal","doi":"10.1177/11206721251334497","DOIUrl":null,"url":null,"abstract":"<p><p>PurposeTo report a case of proliferative diabetic retinopathy (DR) complicated by concomitant undiagnosed chronic myeloid leukemia (CML).MethodsA known diabetic presented with minimal vitreous hemorrhage in left eye, along with Roth's spots and retinal hemorrhages in both eyes. Fundus fluorescein angiography revealed Proliferative DR with mid peripheral capillary non perfusion and neovascularization. Panretinal photocoagulation was performed, but the patient subsequently developed a vitreous hemorrhage in both eyes, necessitating bilateral vitrectomy. Post operatively both eyes had unexpected massive sub-conjunctival and recurrent vitreous hemorrhage.ResultsRepeat surgery with vitreous lavage and silicon oil injection stabilized the ocular condition. Initial hematological evaluation at baseline had elevated blood sugar levels with normal cell counts. However, six months later, repeat testing revealed leukocytosis, prompting further investigation and a subsequent diagnosis of CML. After treatment for CML silicone oil was removed with a final visual acuity of 20/40 in both eyes.ConclusionThis case reveals the intricate interplay between CML and DR. Subtle ocular findings, including Roth spots, mid-peripheral capillary non-perfusion areas with mid peripheral neovascularization can indicate coexistent CML. Diagnosis of CML may be obscured by normal blood counts, and an interdisciplinary collaboration is required in managing complex cases.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP68-NP72"},"PeriodicalIF":1.4000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unrecognized chronic myeloid leukemia manifesting as hemorrhagic complications in proliferative diabetic retinopathy: A case report.\",\"authors\":\"Shreeya Hinge, Shivraj Tagare, Manavi D Sindal\",\"doi\":\"10.1177/11206721251334497\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>PurposeTo report a case of proliferative diabetic retinopathy (DR) complicated by concomitant undiagnosed chronic myeloid leukemia (CML).MethodsA known diabetic presented with minimal vitreous hemorrhage in left eye, along with Roth's spots and retinal hemorrhages in both eyes. Fundus fluorescein angiography revealed Proliferative DR with mid peripheral capillary non perfusion and neovascularization. Panretinal photocoagulation was performed, but the patient subsequently developed a vitreous hemorrhage in both eyes, necessitating bilateral vitrectomy. Post operatively both eyes had unexpected massive sub-conjunctival and recurrent vitreous hemorrhage.ResultsRepeat surgery with vitreous lavage and silicon oil injection stabilized the ocular condition. Initial hematological evaluation at baseline had elevated blood sugar levels with normal cell counts. However, six months later, repeat testing revealed leukocytosis, prompting further investigation and a subsequent diagnosis of CML. After treatment for CML silicone oil was removed with a final visual acuity of 20/40 in both eyes.ConclusionThis case reveals the intricate interplay between CML and DR. Subtle ocular findings, including Roth spots, mid-peripheral capillary non-perfusion areas with mid peripheral neovascularization can indicate coexistent CML. Diagnosis of CML may be obscured by normal blood counts, and an interdisciplinary collaboration is required in managing complex cases.</p>\",\"PeriodicalId\":12000,\"journal\":{\"name\":\"European Journal of Ophthalmology\",\"volume\":\" \",\"pages\":\"NP68-NP72\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Ophthalmology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/11206721251334497\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/11206721251334497","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Unrecognized chronic myeloid leukemia manifesting as hemorrhagic complications in proliferative diabetic retinopathy: A case report.
PurposeTo report a case of proliferative diabetic retinopathy (DR) complicated by concomitant undiagnosed chronic myeloid leukemia (CML).MethodsA known diabetic presented with minimal vitreous hemorrhage in left eye, along with Roth's spots and retinal hemorrhages in both eyes. Fundus fluorescein angiography revealed Proliferative DR with mid peripheral capillary non perfusion and neovascularization. Panretinal photocoagulation was performed, but the patient subsequently developed a vitreous hemorrhage in both eyes, necessitating bilateral vitrectomy. Post operatively both eyes had unexpected massive sub-conjunctival and recurrent vitreous hemorrhage.ResultsRepeat surgery with vitreous lavage and silicon oil injection stabilized the ocular condition. Initial hematological evaluation at baseline had elevated blood sugar levels with normal cell counts. However, six months later, repeat testing revealed leukocytosis, prompting further investigation and a subsequent diagnosis of CML. After treatment for CML silicone oil was removed with a final visual acuity of 20/40 in both eyes.ConclusionThis case reveals the intricate interplay between CML and DR. Subtle ocular findings, including Roth spots, mid-peripheral capillary non-perfusion areas with mid peripheral neovascularization can indicate coexistent CML. Diagnosis of CML may be obscured by normal blood counts, and an interdisciplinary collaboration is required in managing complex cases.
期刊介绍:
The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.