在赞比亚小反刍动物害虫-小反刍动物病毒（PPRV）监测期间检测到犬瘟热病毒（CDV）中和抗体。

IF 2.3 2区农林科学 Q1 VETERINARY SCIENCES

BMC Veterinary Research Pub Date : 2025-04-30 DOI:10.1186/s12917-025-04732-w

Sara Lysholm, Nicola Logan, Johanna F Lindahl, Mikael Berg, Elin Johansson, Pernilla Karlsson Bergkvist, George Dautu, Ricky Chazya, Brian J Willett, Musso Munyeme, Jonas Johansson Wensman

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引用次数: 0

摘要

犬瘟热病毒（CDV）在赞比亚流行，而小反刍动物害虫病毒（PPRV）尚未发现。本研究采用c-ELISA法对962只养殖山羊和237只非正规市场小反刍动物进行PPRV抗体检测。由于交叉反应性的考虑，用病毒中和试验（VNA）重新分析了一个亚群（n = 29）的PPRV和CDV抗体。c-ELISA检测猪场PPRV血清阳性率为6.44%，市场阳性率为3.80%。而VNA未检测到PPRV抗体，45%（13/29）检测到CDV阳性，可能提示交叉反应。鉴于这项研究的局限性，需要进一步的研究来确定PPRV是否在赞比亚存在，并评估潜在的交叉反应性。

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Detection of canine distemper virus (CDV) neutralising antibodies in small ruminants during peste-des-petits-ruminants virus (PPRV) surveillance in Zambia.

Canine distemper virus (CDV) is endemic in Zambia, while peste-des-petits-ruminants virus (PPRV) has not been detected. This study screened 962 farmed goats and 237 small ruminants at informal markets for PPRV antibodies using c-ELISA. A subset (n = 29) was re-analysed with virus neutralisation assays (VNA) for antibodies to PPRV and CDV due to cross-reactivity concerns. c-ELISA indicated 6.44% PPRV seroprevalence on farms and 3.80% at markets. While VNA detected no PPRV antibodies, 45% (13/29) tested positive for CDV, possibly suggesting cross-reactivity. Given the study's limitations, further research is needed to determine whether PPRV is present in Zambia and assess potential cross-reactivity.

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来源期刊

BMC Veterinary Research VETERINARY SCIENCES-

CiteScore

4.80

自引率

3.80%

发文量

420

审稿时长

3-6 weeks

期刊介绍： BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.