活体状态下树突突触整合模式。

IF 3.2 3区 生物学 Q2 BIOPHYSICS
Biophysical journal Pub Date : 2025-06-17 Epub Date: 2025-04-30 DOI:10.1016/j.bpj.2025.04.028
Cesar C Ceballos, Rodrigo F O Pena
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引用次数: 0

摘要

神经密码仍未被发现,而了解类似活体条件下的突触输入整合只是解开它的第一步。突触信号通过两种主要的时间和模式产生快速的树突尖峰:重合检测和整合。在重合检测中,树突只有在多个传入信号快速连续到达时才会放电,而整合则涉及突触后电位在较长时间内的总和,且膜渗漏最小。这一过程受到离子性质的影响,特别是当膜电位接近放电阈值时,其中灭活电流起关键作用。然而,在类活体条件下,这些电流对时间总和的调制尚未得到深入研究。在我们的研究中,我们使用计算机模拟单个树突分支来研究三种灭活电流——a型钾、t型钙和瞬态钠——如何影响时间累加。我们发现钙和钠电流促进了树突的整合行为,而钾电流增强了它们作为巧合探测器的能力。通过调整树突中这些电流的水平,神经元可以灵活地在整合和巧合检测模式之间切换,为它们提供了一种通用的机制,用于多路复用等复杂任务。这种灵活性可能是理解神经回路如何实时处理信息的关键。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dendritic synaptic integration modes under in vivo-like states.

The neural code remains undiscovered and understanding synaptic input integration under in vivo-like conditions is just the initial step toward unraveling it. Synaptic signals generate fast dendritic spikes through two main modes of temporal summation: coincidence detection and integration. In coincidence detection, dendrites fire only when multiple incoming signals arrive in rapid succession, whereas integration involves summation of postsynaptic potentials over longer periods with minimal membrane leakage. This process is influenced by ionic properties, especially as the membrane potential approaches the firing threshold, where inactivating currents play a critical role. However, the modulation of temporal summation by these currents under in vivo-like conditions has not been thoroughly studied. In our research, we used computer simulations of a single dendritic branch to investigate how three inactivating currents-A-type potassium, T-type calcium, and transient sodium-affect temporal summation. We found that calcium and sodium currents promote integrative behavior in dendrites, while potassium currents enhance their ability to act as coincidence detectors. By adjusting the levels of these currents in dendrites, neurons can flexibly switch between integration and coincidence detection modes, providing them with a versatile mechanism for complex tasks such as multiplexing. This flexibility could be key to understanding how neural circuits process information in real time.

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来源期刊
Biophysical journal
Biophysical journal 生物-生物物理
CiteScore
6.10
自引率
5.90%
发文量
3090
审稿时长
2 months
期刊介绍: BJ publishes original articles, letters, and perspectives on important problems in modern biophysics. The papers should be written so as to be of interest to a broad community of biophysicists. BJ welcomes experimental studies that employ quantitative physical approaches for the study of biological systems, including or spanning scales from molecule to whole organism. Experimental studies of a purely descriptive or phenomenological nature, with no theoretical or mechanistic underpinning, are not appropriate for publication in BJ. Theoretical studies should offer new insights into the understanding ofexperimental results or suggest new experimentally testable hypotheses. Articles reporting significant methodological or technological advances, which have potential to open new areas of biophysical investigation, are also suitable for publication in BJ. Papers describing improvements in accuracy or speed of existing methods or extra detail within methods described previously are not suitable for BJ.
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