血管活性肠肽：一种在帕金森病中起重要作用的神经肽。

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Neuropharmacology Pub Date : 2025-05-08 DOI:10.2174/011570159X374501250425045109

Wenhui Fan, Ke Li, Ruohua Wang, Rongsha Chen, Yiben Liu, Zhongshan Yang, Ninghui Zhao, Jinyuan Yan

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引用次数: 0

摘要

帕金森病（PD）的主要特征是僵硬和震颤，其病理上与α -突触核蛋白聚集有关，特别是在中脑多巴胺能神经元中。由于它是一种多因素疾病，目前没有有效的治疗方法，只有缓解治疗。血管活性肠肽（Vasoactive intestinal peptide， VIP）是一种由28个氨基酸组成的神经递质，广泛分布于中枢和周围神经系统，具有广泛的生物学效应。研究表明，VIP具有抗炎、抗氧化、抗凋亡的作用，可调节神经胶质细胞和免疫细胞，保护和修复神经细胞。本文就VIP作为脑肠肽治疗帕金森病的研究进展及未来可能的研究方向进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Vasoactive Intestinal Peptide: A Neuropeptide that Plays an Important Role in Parkinson's Disease.

Parkinson's disease (PD) is primarily characterized by rigidity and tremor, which are pathologically associated with α -synuclein aggregation, especially in dopaminergic neurons in the midbrain. As it is a multi-factorial disease, there are currently no effective treatments but only mitigative therapies. Vasoactive intestinal peptide (VIP), a 28-amino acid neurotransmitter, is widely distributed in both the central and peripheral nervous system with a broad biological effect. Studies have shown that VIP exhibits anti-inflammatory, antioxidant, and anti-apoptotic effects and regulates glial cells and immune cells to protect and repair nerve cells. This article reviews the research progress of VIP as a brain-gut peptide in the treatment of PD and possible future research directions.

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来源期刊

Current Neuropharmacology 医学-神经科学

CiteScore

8.70

自引率

1.90%

发文量

369

审稿时长

>12 weeks

期刊介绍： Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience. The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.