解码mirna的分子机制:精神分裂症发病机制中的蛋白质相互作用。

IF 1.9 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sumel Ashique, Radheshyam Pal, Anas Islam, Himanshu Sharma, Subhajit Mandal, Sanjesh Kumar, Mansi Singh, Samy Selim, Soad K Al Jaouni, Amisha Raikar, Lavanya Lakshminarayana, Bhavinee Sharma, Rashmi Pathak
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引用次数: 0

摘要

现在诊断精神分裂症主要是根据症状和体征,而不是病人的病理和生理标志。虽然肿瘤学家曾经对他们的病人经历了长期的缓解感到满意,但今天,他们正在领导研究分子靶向药物的创新治疗方法,以及提高诊断准确性和减轻疾病进展症状的策略。因为生物标志物反映了生物体的生理、物理和生化状态,所以它们非常有益,在现实世界中有广泛的用途。血液生物标志物的鉴定可能为研究精神分裂症开辟新的途径。MicroRNAs (miRNAs)可以作为精神分裂症的诊断指标,因为它们的异常表达最近与疾病的病理生理有关。尽管普遍认为发育和遗传因素在精神分裂症的病理生理中起着关键作用,但精神分裂症的确切病因学过程在很大程度上仍然未知。近几十年来,mirna作为一种重要的转录后调控因子在基因表达调控中得到了认可。mirna对大脑发育和神经可塑性的重要性已得到证实。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decoding the Molecular Mechanisms of miRNAs: Protein Interactions in Schizophrenia Pathogenesis.

Schizophrenia is now diagnosed mostly based on symptoms and physical signs rather than the patient's pathological and physiological markers. While oncologists once felt satisfied when their patients experienced a long remission, today, they are leading research into innovative treatments with molecularly targeted drugs, as well as strategies to enhance diagnostic accuracy and alleviate symptoms as the disease advances.Because biomarkers reflect an organism's physiological, physical, and biochemical state, they are very beneficial and have a wide range of real-- world uses. The identification of blood biomarkers may open up new avenues for studying schizophrenia. MicroRNAs (miRNAs) may serve as diagnostic indicators for schizophrenia as their abnormal expression has recently been linked to the disease's pathophysiology. The precise etiological process of schizophrenia remains largely unknown despite the general agreement that developmental and genetic factors play a critical role in the pathophysiology of the disorder. miRNAs have gained recognition as an essential post-transcriptional regulator in the regulation of gene expression in recent decades. The importance of miRNAs for brain development and neuroplasticity is well established.

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来源期刊
Current protein & peptide science
Current protein & peptide science 生物-生化与分子生物学
CiteScore
5.20
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.
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