Exploration of CT-based discrimination and diagnosis of various pathological types of ground glass nodules in the lungs.

Purpose: This study aims to examine the diagnostic usefulness of CT imaging in distinguishing between various pathological forms of lung ground-glass nodules (GGNs).

Methods: We conducted a retrospective analysis on 210 patients with lung ground-glass nodules (GGNs) who received diagnosis and treatment at our hospital between January 2021 and May 2024. Every patient had comprehensive imaging and pathology investigations. Lesion size, three-dimensional ratio, two-dimensional ratio, size of solid components, form, spiculation, lobulation, and cavitation were studied across several pathological kinds of pulmonary ground-glass nodules (GGNs).

Results: Of the 210 patients, 51 were diagnosed with benign conditions, while 159 had malignant lesions distributed across AIS, MIA, and IAC. The imaging data revealed that pulmonary ground-glass nodules (GGNs) exhibiting spiculation, lobulation, cavitation, pleural indentation, irregular shape, and fuzzy borders were considerably more prevalent in the inflammatory group, atypical adenomatous hyperplasia (AAH) group, adenocarcinoma in situ (AIS) group, minimally invasive adenocarcinoma (MIA) group, and invasive adenocarcinoma (IAC) group. These differences were statistically significant (P < 0.05). Significant variations in lesion size and size of solid components were observed among the groups, with the inflammatory group having the smallest size, followed by the AAH group, AIS group, MIA group, and finally the IAC group (P < 0.05). Nevertheless, there were no statistically significant disparities in the three-dimensional ratio and two-dimensional ratio across the five groups (P > 0.05). The calculated areas under the curve for distinguishing pre-invasive lesions from MIA and MIA from IAC, depending on the size of solid components, were 0.705 and 0.814, respectively. These values indicate a high diagnostic accuracy.

Conclusion: A thorough examination of the CT imaging characteristics of ground-glass nodules is crucial for accurately distinguishing between various pathological forms of pulmonary GGNs.