应用DTI-ALPS研究痉挛性双瘫脑瘫患者运动障碍与淋巴系统功能障碍的关系。

IF 2.6 3区医学 Q2 CLINICAL NEUROLOGY

Neuroradiology Pub Date : 2025-08-01 Epub Date: 2025-04-25 DOI:10.1007/s00234-025-03628-8

Mengyi Wang, Xiaochen Jiang, Binbin Nie, Han Meng, Hao Song, Ying Liu, Jiqiang Liu, Xuetao Mu

{"title":"应用DTI-ALPS研究痉挛性双瘫脑瘫患者运动障碍与淋巴系统功能障碍的关系。","authors":"Mengyi Wang, Xiaochen Jiang, Binbin Nie, Han Meng, Hao Song, Ying Liu, Jiqiang Liu, Xuetao Mu","doi":"10.1007/s00234-025-03628-8","DOIUrl":null,"url":null,"abstract":"Background: The role of the glymphatic system in occult cerebral palsy (CP) remains unclear. In this study, glymphatic system function and its association with motor impairment in occult CP patients was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS).Methods: This retrospective study used DTI to calculate the diffusivity values along the x-, y-, and z-axes in 27 occult CP patients and 27 matched controls. A correlation analysis the ALPS index, derived from perivascular, projection, and association fibres, and with the Gross Motor Function Classification (GMFSC) grade was performed.Results: We found significant differences in the ALPS index between occult CP patients and healthy controls (HCs). The ALPS index of the lateral hemisphere was lower in occult CP patients than in HCs (left: 1.51 ± 0.20 vs. 1.68 ± 0.24, p = 0.011; right: 1.51 ± 0.20 vs. 1.65 ± 0.24, p = 0.019). Correlation analysis revealed a negative correlation between the ALPS index in the lateral hemisphere and the GMFSC grade (left: r = -0.61, p = 0.004; right: r = -0.48, p = 0.015).Conclusion: Our findings show that occult CP patients have reduced ALPS indices, suggesting glymphatic system dysfunction. Lower ALPS indices were associated with higher motor function grades, indicating a potential link between glymphatic system dysfunction and motor impairment in CP patients.","PeriodicalId":19422,"journal":{"name":"Neuroradiology","volume":" ","pages":"2097-2106"},"PeriodicalIF":2.6000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between movement impairments and glymphatic system dysfunction in spastic diplegic cerebral palsy using DTI-ALPS.\",\"authors\":\"Mengyi Wang, Xiaochen Jiang, Binbin Nie, Han Meng, Hao Song, Ying Liu, Jiqiang Liu, Xuetao Mu\",\"doi\":\"10.1007/s00234-025-03628-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: The role of the glymphatic system in occult cerebral palsy (CP) remains unclear. In this study, glymphatic system function and its association with motor impairment in occult CP patients was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS).Methods: This retrospective study used DTI to calculate the diffusivity values along the x-, y-, and z-axes in 27 occult CP patients and 27 matched controls. A correlation analysis the ALPS index, derived from perivascular, projection, and association fibres, and with the Gross Motor Function Classification (GMFSC) grade was performed.Results: We found significant differences in the ALPS index between occult CP patients and healthy controls (HCs). The ALPS index of the lateral hemisphere was lower in occult CP patients than in HCs (left: 1.51 ± 0.20 vs. 1.68 ± 0.24, p = 0.011; right: 1.51 ± 0.20 vs. 1.65 ± 0.24, p = 0.019). Correlation analysis revealed a negative correlation between the ALPS index in the lateral hemisphere and the GMFSC grade (left: r = -0.61, p = 0.004; right: r = -0.48, p = 0.015).Conclusion: Our findings show that occult CP patients have reduced ALPS indices, suggesting glymphatic system dysfunction. Lower ALPS indices were associated with higher motor function grades, indicating a potential link between glymphatic system dysfunction and motor impairment in CP patients.\",\"PeriodicalId\":19422,\"journal\":{\"name\":\"Neuroradiology\",\"volume\":\" \",\"pages\":\"2097-2106\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neuroradiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00234-025-03628-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroradiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00234-025-03628-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

背景：淋巴系统在隐匿性脑瘫（CP）中的作用尚不清楚。本研究采用沿血管周围间隙弥散张量图像分析（DTI-ALPS）研究隐匿性CP患者的淋巴系统功能及其与运动障碍的关系。方法：回顾性研究采用DTI计算27例隐匿性CP患者和27例对照患者沿x、y、z轴的弥漫性值。对血管周围纤维、投射纤维和联合纤维的ALPS指数与大运动功能分类（GMFSC）等级进行相关性分析。结果：我们发现隐匿性CP患者与健康对照（hc）之间的ALPS指数有显著差异。隐匿性CP患者的侧半球ALPS指数低于hcc患者(左：1.51±0.20 vs 1.68±0.24,p = 0.011；右侧：1.51±0.20 vs. 1.65±0.24,p = 0.019)。相关分析显示，侧半球ALPS指数与GMFSC分级呈负相关(左：r = -0.61, p = 0.004；右：r = -0.48, p = 0.015)。结论：隐匿性CP患者的ALPS指数降低，提示淋巴系统功能障碍。较低的ALPS指数与较高的运动功能等级相关，表明CP患者淋巴系统功能障碍与运动功能障碍之间存在潜在联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Association between movement impairments and glymphatic system dysfunction in spastic diplegic cerebral palsy using DTI-ALPS.

Background: The role of the glymphatic system in occult cerebral palsy (CP) remains unclear. In this study, glymphatic system function and its association with motor impairment in occult CP patients was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS).

Methods: This retrospective study used DTI to calculate the diffusivity values along the x-, y-, and z-axes in 27 occult CP patients and 27 matched controls. A correlation analysis the ALPS index, derived from perivascular, projection, and association fibres, and with the Gross Motor Function Classification (GMFSC) grade was performed.

Results: We found significant differences in the ALPS index between occult CP patients and healthy controls (HCs). The ALPS index of the lateral hemisphere was lower in occult CP patients than in HCs (left: 1.51 ± 0.20 vs. 1.68 ± 0.24, p = 0.011; right: 1.51 ± 0.20 vs. 1.65 ± 0.24, p = 0.019). Correlation analysis revealed a negative correlation between the ALPS index in the lateral hemisphere and the GMFSC grade (left: r = -0.61, p = 0.004; right: r = -0.48, p = 0.015).

Conclusion: Our findings show that occult CP patients have reduced ALPS indices, suggesting glymphatic system dysfunction. Lower ALPS indices were associated with higher motor function grades, indicating a potential link between glymphatic system dysfunction and motor impairment in CP patients.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Neuroradiology 医学-核医学

CiteScore

5.30

自引率

3.60%

发文量

214

审稿时长

4-8 weeks

期刊介绍： Neuroradiology aims to provide state-of-the-art medical and scientific information in the fields of Neuroradiology, Neurosciences, Neurology, Psychiatry, Neurosurgery, and related medical specialities. Neuroradiology as the official Journal of the European Society of Neuroradiology receives submissions from all parts of the world and publishes peer-reviewed original research, comprehensive reviews, educational papers, opinion papers, and short reports on exceptional clinical observations and new technical developments in the field of Neuroimaging and Neurointervention. The journal has subsections for Diagnostic and Interventional Neuroradiology, Advanced Neuroimaging, Paediatric Neuroradiology, Head-Neck-ENT Radiology, Spine Neuroradiology, and for submissions from Japan. Neuroradiology aims to provide new knowledge about and insights into the function and pathology of the human nervous system that may help to better diagnose and treat nervous system diseases. Neuroradiology is a member of the Committee on Publication Ethics (COPE) and follows the COPE core practices. Neuroradiology prefers articles that are free of bias, self-critical regarding limitations, transparent and clear in describing study participants, methods, and statistics, and short in presenting results. Before peer-review all submissions are automatically checked by iThenticate to assess for potential overlap in prior publication.