Lipoic acid as a protective agent against lipopolysaccharide and other natural toxins: a comprehensive review.

Alpha-lipoic acid, also known as lipoate or lipoic acid (LA), is naturally present in the mitochondria of cells, where it functions as a cofactor for dehydrogenase enzyme complexes. It has also been reported that LA is a potent antioxidant. Not only does it scavenge free radicals directly, but it can also regenerate other essential cellular antioxidants. LA exhibits various anti-inflammatory effects and offers protection to mitochondria. Numerous studies have assessed the potential protective effects of LA against natural toxins, including lipopolysaccharides, galactosamine, mycotoxins, snake venoms, and toxins derived from cyanobacteria and plants. In general, the results of these studies indicate that LA can be effective in mitigating various toxicities, primarily due to the previously mentioned capabilities. Furthermore, novel mechanisms have been proposed for LA against specific toxins, for example, direct inactivation of secretory phospholipase A₂ in some snake venoms or enhancement of p-glycoprotein activity to prevent saxitoxin entry into the neuronal cells. However, the gaps in the available data from most animal experiments conducted to date have resulted in insufficient evidence to justify further clinical evaluations of the effects of LA on human poisoning cases. Consequently, more extensive research is required to address these gaps and fully realize the therapeutic potential of this valuable substance.