维生素D及其在风湿病中的作用。

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2025-04-09 DOI:10.3390/metabo15040259

Maritza Vidal, Nancy E Lane

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引用次数: 0

摘要

维生素D是一种脂溶性分子，具有多效性，作为类固醇激素作用于三个主要器官：肠、骨和肾。它在骨骼水平上最著名的功能是调节骨代谢和矿化。1983年，研究人员发现免疫细胞表面存在维生素D受体，从而发现了维生素D在免疫和炎症过程中的新功能。目前，我们知道维生素D通过下调抑制产生炎症细胞因子的细胞来调节适应性免疫系统，是免疫和炎症反应的重要调节剂。本文将对维生素D的合成、代谢途径及其在风湿性自身免疫性疾病中的作用进行综述。

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Vitamin D and Its Role in Rheumatic Diseases.

Vitamin D is a fat-soluble molecule with pleiotropic effects, acting as a steroid hormone on three main organs: the intestine, bone, and kidney. Among its best-known functions at the skeletal level are regulating bone metabolism and mineralization. In 1983, the presence of vitamin D receptors on the surface of immune cells was described, which led to the discovery of new functions on immunological and inflammatory processes. Currently, we know that vitamin D modulates the adaptative immune system by suppressing cells that produce inflammatory cytokines by downregulation, acting as an important regulator of immunity and the inflammatory response. In this article, we will review the synthesis, metabolic pathways, and the role of vitamin D in rheumatic autoimmune diseases.

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.