Vivien Latuske, Stefan Erfurt, Daniel Patschan, Meike Hoffmeister
{"title":"终末期慢性肾病影响血清诺斯特宁周转。","authors":"Vivien Latuske, Stefan Erfurt, Daniel Patschan, Meike Hoffmeister","doi":"10.1159/000545521","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Serum Nostrin was recently identified as novel predictor of important clinical outcomes in acute kidney injury (AKI) and has also emerged as a predictor of recovery of kidney function (ROKF) in AKI patients. ROKF is a critical factor for the transition of AKI into chronic kidney disease (CKD). Therefore the aim of the present study was to evaluate serum Nostrin levels in CKD patients.</p><p><strong>Methods: </strong>Blood samples were collected from CKD patients before and after dialysis, and serum Nostrin levels were determined using ELISAs.</p><p><strong>Results: </strong>Serum Nostrin levels were previously shown to be significantly increased in AKI patients in comparison with healthy controls. In CKD patients, the levels of serum Nostrin were further increased without significant differences of Nostrin concentrations before and after dialysis.</p><p><strong>Conclusion: </strong>The further elevation of serum Nostrin concentrations in CKD in comparison with AKI indicates a significant impairment of Nostrin turnover and supports the possible suitability of Nostrin as potential diagnostic value in both AKI and CKD.</p>","PeriodicalId":17813,"journal":{"name":"Kidney & blood pressure research","volume":" ","pages":"321-324"},"PeriodicalIF":2.3000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"End-Stage Chronic Kidney Disease Affects Serum Nostrin Turnover.\",\"authors\":\"Vivien Latuske, Stefan Erfurt, Daniel Patschan, Meike Hoffmeister\",\"doi\":\"10.1159/000545521\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Serum Nostrin was recently identified as novel predictor of important clinical outcomes in acute kidney injury (AKI) and has also emerged as a predictor of recovery of kidney function (ROKF) in AKI patients. ROKF is a critical factor for the transition of AKI into chronic kidney disease (CKD). Therefore the aim of the present study was to evaluate serum Nostrin levels in CKD patients.</p><p><strong>Methods: </strong>Blood samples were collected from CKD patients before and after dialysis, and serum Nostrin levels were determined using ELISAs.</p><p><strong>Results: </strong>Serum Nostrin levels were previously shown to be significantly increased in AKI patients in comparison with healthy controls. In CKD patients, the levels of serum Nostrin were further increased without significant differences of Nostrin concentrations before and after dialysis.</p><p><strong>Conclusion: </strong>The further elevation of serum Nostrin concentrations in CKD in comparison with AKI indicates a significant impairment of Nostrin turnover and supports the possible suitability of Nostrin as potential diagnostic value in both AKI and CKD.</p>\",\"PeriodicalId\":17813,\"journal\":{\"name\":\"Kidney & blood pressure research\",\"volume\":\" \",\"pages\":\"321-324\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Kidney & blood pressure research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000545521\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Kidney & blood pressure research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545521","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/14 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
Introduction: Serum Nostrin was recently identified as novel predictor of important clinical outcomes in acute kidney injury (AKI) and has also emerged as a predictor of recovery of kidney function (ROKF) in AKI patients. ROKF is a critical factor for the transition of AKI into chronic kidney disease (CKD). Therefore the aim of the present study was to evaluate serum Nostrin levels in CKD patients.
Methods: Blood samples were collected from CKD patients before and after dialysis, and serum Nostrin levels were determined using ELISAs.
Results: Serum Nostrin levels were previously shown to be significantly increased in AKI patients in comparison with healthy controls. In CKD patients, the levels of serum Nostrin were further increased without significant differences of Nostrin concentrations before and after dialysis.
Conclusion: The further elevation of serum Nostrin concentrations in CKD in comparison with AKI indicates a significant impairment of Nostrin turnover and supports the possible suitability of Nostrin as potential diagnostic value in both AKI and CKD.
期刊介绍：
This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.
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