端粒选择性延长(ALT)癌的治疗机会

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Jixuan Gao, Hilda A Pickett
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引用次数: 0

摘要

依赖于端粒选择性延长(ALT)途径激活的癌症主要影响儿童和青少年,并且由于缺乏临床有效的靶向治疗而导致灾难性后果。近年来,我们对ALT机制的理解呈指数级增长,这导致了对这些癌症患者的许多治疗靶点和策略的确定。这些方法包括靶向复制叉重塑和DNA损伤反应途径以加剧端粒特异性复制应激,抑制ALT介导的端粒合成以诱导端粒功能障碍,以及使用溶瘤病毒选择性杀死ALT癌细胞。在此,我们将评估这些治疗策略的优点和缺点,并讨论当前的诊断机会,这些诊断机会是指导ALT治疗对患者的必要伴奏。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic Opportunities for Alternative Lengthening of Telomeres (ALT) Cancers.

Cancers that rely on activation of the alternative lengthening of telomeres (ALT) pathway predominantly affect children and adolescents, and are associated with catastrophic outcomes due to a lack of clinically effective, targeted therapeutics. The exponential rise in our understanding of the ALT mechanism in recent years has led to the identification of many therapeutic targets and strategies for patients suffering from these cancers. These include targeting replication fork remodelers and DNA damage response pathways to exacerbate telomere-specific replication stress, inhibiting ALT-mediated telomere synthesis to induce telomere dysfunction, and using oncolytic viruses to selectively kill ALT cancer cells. Herein we will evaluate the advantages and shortfalls of these therapeutic strategies, and discuss current diagnostic opportunities that are a necessary accompaniment to direct ALT therapeutics to patients.

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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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