四环素在糖尿病视网膜病变患者中的短期疗效。

IF 2.8 4区 医学 Q1 OPHTHALMOLOGY
Ahmed M Alshaikhsalama, Amer F Alsoudi, Karen M Wai, Euna Koo, Prithvi Mruthyunjaya, Christina Y Weng, Ehsan Rahimy
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引用次数: 0

摘要

目的:探讨四环素与糖尿病视网膜病变(DR)患者短期视力威胁并发症(VTC)发生的关系。方法:使用一个未识别的数据库,在倾向评分匹配(PSM)前分别纳入4596例与四环素使用相关的严重非增殖性糖尿病视网膜病变(NPDR)或增殖性糖尿病视网膜病变(PDR)患者和87974例NPDR或PDR但未使用四环素的患者。PSM后,每个队列中有4576例患者进行分析。发生VTC的发生率,包括糖尿病性黄斑水肿(DME)、玻璃体出血(VH)、牵拉性视网膜脱离(TRD)、新生血管性青光眼(NVG),以及随后需要进行眼部干预,包括玻璃体内注射抗血管内皮生长因子(VEGF)、全视网膜光凝(PRP)或玻璃体平面部切除术(PPV)。结果:DR和反复使用四环素的患者发生DME的风险降低(RR: 0.45, 95% CI: 0.28-0.72;p = 0.009)和VH (RR: 0.37, 95% CI: 0.20-0.69;P = 0.001),与未使用四环素的队列在6个月和1年时相比。此外,随后需要抗vegf的风险降低(RR: 0.25, 95% CI: 0.13-0.47;p = 0.003)和PRP (RR: 0.40, 95% CI: 0.19-0.84;P = 0.012)与四环素初始组在6个月和1年的比较。在两组患者中,NVG、TRD的发展或PPV的需求没有显著差异。结论:与未接受四环素治疗的患者相比,反复使用四环素可潜在降低发生DME、VH的短期风险,并需要后续抗vegf或PRP治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Short-term effects of tetracycline use in patients with diabetic retinopathy.

Objective: To investigate the association between tetracycline use and the development of short-term vision threatening complications (VTC) among patients with diabetic retinopathy (DR).

Methods: Using a deidentified database, 4 596 patients with severe nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) associated with tetracycline use versus 87,974 patients with NPDR or PDR but no tetracycline use, respectively, were included before propensity score matching (PSM). After PSM, 4 576 patients in each cohort were analyzed. Incidence of developing VTC, including diabetic macular edema (DME), vitreous hemorrhage (VH), tractional retinal detachment (TRD), neovascular glaucoma (NVG), and subsequent need for ocular interventions including intravitreal anti-vascular endothelial growth factor (VEGF) injections, panretinal photocoagulation (PRP), or pars plana vitrectomy (PPV).

Results: Patients with DR and repeated tetracycline use had a reduced risk of developing DME (RR: 0.45, 95% CI: 0.28-0.72; p = 0.009) and VH (RR: 0.37, 95% CI: 0.20-0.69; p = 0.001) compared to the tetracycline-naive cohort at 6 months and 1 year. Further, there was a reduced risk of subsequent need for anti-VEGF (RR: 0.25, 95% CI: 0.13-0.47; p = 0.003) and PRP (RR: 0.40, 95% CI: 0.19-0.84; p = 0.012) in the tetracycline cohort compared to the tetracycline-naive group at 6 months and 1 year. There were no significant differences in the development of NVG, TRD, or the requirement for PPV between both cohorts.

Conclusions: Repeated tetracycline use was associated with a potentially reduced short-term risk of developing DME, VH, and needing subsequent anti-VEGF or PRP therapy versus tetracycline naive patients.

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来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
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