镜像疗法减少中风患者运动网络的过度变异性:一项随机对照试验。

IF 3.4 3区 医学 Q1 REHABILITATION
Kexu Zhang, Li Ding, Xu Wang, Jinyang Zhuang, Shanbao Tong, Jie Jia, Xiaoli Guo
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引用次数: 0

摘要

背景:镜像疗法(MT)已被证明是促进脑卒中后运动恢复的有效干预手段。现有的神经影像学研究表明,MT的疗效与其增加双侧M1脑活动强度和功能连通性的作用有关。然而,它对大脑动力学的调节,也具有生理意义,仍然未知。目的:探讨MT对脑卒中患者脑动力学的潜在影响。设计:随机、单盲、对照试验。背景:住院。人群:50例首次单侧卒中运动功能障碍患者被招募并随机分配到MT组(n =25)或常规治疗(CT)组(n =25)进行为期4周的干预。方法:干预前后分别进行运动功能评估和静息状态fMRI扫描。来自16名健康受试者的图像作为对照。使用动态低频波动分数幅值(dfALFF)和动态体素镜像同伦连通性(dVMHC)对fMRI数据进行动态分析。结果:在脑卒中患者中观察到异常动力学,其特征是自发活动的变异性增加(稳定性降低)和感觉运动网络的半球间功能连接。MT而不是CT干预导致同侧初级运动皮层(M1)和半球间M1功能连通性的自发活动变异性降低,这进一步显示出与运动改善的相关性。值得注意的是,自发性活动可变性的降低在预测运动恢复与半球间功能连接可变性的降低方面显示了显著的中介作用。结论:MT可能会减少半球间M1功能连通性的过度变异性,从而稳定同侧M1的活动,从而促进运动恢复。临床康复影响:本研究强调了MT在解决异常脑动力学方面的独特作用,强调了它对标准康复方案的补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial.

Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial.

Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial.

Mirror therapy reduces excessive variability of motor network in stroke patients: a randomized controlled trial.

Background: Mirror therapy (MT) has been demonstrated as an effective intervention for promoting motor recovery post-stroke. Existing neuroimaging studies have demonstrated that the efficacy of MT is associated with its effect to increase the strength of brain activity and functional connectivity in the bilateral M1. However, its modulation on brain dynamics, which also hold physiological significance, remains unknown.

Aim: To investigate the potential influence of MT on brain dynamics in stroke patients.

Design: A randomized, single-blinded, controlled trial.

Setting: Inpatient.

Population: Fifty first-ever unilateral stroke patients with motor dysfunctions were recruited and randomly assigned to either an MT group (N.=25) or a conventional therapy (CT) group (N.=25) for a 4-week intervention.

Methods: Motor function assessments and resting-state fMRI scans were conducted both before and after the intervention. Images from sixteen healthy subjects were used as controls. A dynamic analysis of the fMRI data was performed using measures of the dynamic fractional amplitude of low-frequency fluctuation (dfALFF) and dynamic voxel-mirrored homotopic connectivity (dVMHC).

Results: Aberrant dynamics, characterized by increased variability (decreased stability) in spontaneous activity and interhemispheric functional connectivity in sensorimotor networks, were observed in stroke patients. MT but not CT intervention led to reduced variability of spontaneous activity in the ipsilesional primary motor cortex (M1) and interhemispheric M1 functional connectivity, which further exhibited a correlation with motor improvement. Notably, reduced variability of spontaneous activity showed significant mediation effects in the prediction of motor recovery with reduced variability of interhemispheric functional connectivity.

Conclusions: MT may reduce the excessive variability of interhemispheric M1 functional connectivity, thereby stabilizing the activity of ipsilesional M1 and then facilitating motor recovery.

Clinical rehabilitation impact: This study highlights the unique role of MT in addressing abnormal brain dynamics, emphasizing its addition to standard rehabilitation protocols.

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来源期刊
CiteScore
8.50
自引率
4.40%
发文量
162
审稿时长
6-12 weeks
期刊介绍: The European Journal of Physical and Rehabilitation Medicine publishes papers of clinical interest in physical and rehabilitation medicine.
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