端粒酶及其相关因子的结构生物学研究。

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Zala Sekne, Patryk Ludzia, Sebastian Balch, Thi Hoang Duong Nguyen
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引用次数: 0

摘要

端粒酶核糖核蛋白(RNP)通过在染色体的3'端不断添加端粒重复序列,在维持端粒长度方面起着至关重要的作用。端粒酶激活与癌症有关,而损害端粒酶功能的突变会导致先天性角化不良等疾病。端粒重复序列的合成需要两种核心端粒酶成分:端粒酶逆转录酶(TERT)和端粒酶RNA (TER)。然而,细胞端粒酶全酶包含多种蛋白质因子,既有组成性的,也有瞬时的相互作用。这些因子对于端粒酶的组装或调控是不可或缺的。本文综述了嗜热四膜菌、酿酒酵母、裂糖菌和人体内端粒酶全酶及其相关因子的结构研究进展。这些研究不仅大大加深了我们对端粒重复合成机制的分子认识,而且也加深了我们对端粒酶相关蛋白的生物学作用的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural Biology of Telomerase and Associated Factors.

Telomerase ribonucleoprotein (RNP) plays a crucial role in maintaining telomere length by processively adding telomeric repeats to the 3' ends of chromosomes. Telomerase activation is linked to cancer, while mutations that compromise telomerase function result in diseases such as dyskeratosis congenita. The synthesis of telomeric repeats necessitates two core telomerase components: telomerase reverse transcriptase (TERT) and telomerase RNA (TER). However, cellular telomerase holoenzymes encompass a diverse range of protein factors, both constitutively and transiently interacting. These factors are integral to telomerase assembly or regulation at telomeres. This review emphasizes recent advancements in structural studies of telomerase holoenzymes and their associated factors from Tetrahymena thermophila, Saccharomyces cerevisiae, Schizosaccharomyces pombe, and humans. These studies have significantly deepened our molecular understanding not only of the mechanism underlying telomeric repeat synthesis but also of the biological roles of telomerase-associated proteins.

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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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