Nginache Nampota-Nkomba, Kareshma Mohanty, Ruxton Adebiyi, Charles Ekeh, Lisa M Schumaker, Kareemah T Suleiman, Laura Powell, Kara Lombardi, Nicholas P Ambulos, Elizabeth Shoyemi, Abdulwasiu B Tiamiyu, Michael G Homan, Mohammad M Sajadi, Søren M Bentzen, Kevin J Cullen, Trevor A Crowell, Rebecca G Nowak
{"title":"阴茎人乳头瘤病毒在包皮环切的少数性行为男性感染和不感染艾滋病毒。","authors":"Nginache Nampota-Nkomba, Kareshma Mohanty, Ruxton Adebiyi, Charles Ekeh, Lisa M Schumaker, Kareemah T Suleiman, Laura Powell, Kara Lombardi, Nicholas P Ambulos, Elizabeth Shoyemi, Abdulwasiu B Tiamiyu, Michael G Homan, Mohammad M Sajadi, Søren M Bentzen, Kevin J Cullen, Trevor A Crowell, Rebecca G Nowak","doi":"10.1097/QAD.0000000000004209","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Understanding the burden of penile human papillomavirus (HPV) among high-risk groups is essential to inform tailored prevention strategies to reduce HPV-related morbidity. We estimated the prevalence of penile HPV and its association with HIV among circumcised sexual minority men (SMM).</p><p><strong>Design: </strong>A cross-sectional study from a community-based cohort of SMM with and without HIV in Nigeria.</p><p><strong>Methods: </strong>Penile swabs were genotyped with a next-generation sequencing assay for any and high-risk HPV (HPV16/18/31/33/35/39/45/51/52/56/58/59/68). HIV status was ascertained using rapid diagnostic tests. Multivariable logistic regression models estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between HIV and any and high-risk penile HPV.</p><p><strong>Results: </strong>Among 498 participants, median age was 24 (interquartile range: 22-28) years and 70.5% (n = 351) were living with HIV. The prevalence of any (n = 362) and high-risk (n = 239) penile HPV was 72.7% [95% confidence interval (95% CI): 68.6-76.4] and 48.0% (95% CI: 43.6-52.4), respectively. The most common high-risk HPV types were 16, 51, 45, and 18, while the most common low-risk types were 6 and 11. HIV was significantly associated with increased odds of any penile HPV (aOR 1.93, 95% CI: 1.20-3.12). Similar to any HPV, the association of HIV with high-risk penile HPV trended in the positive direction (aOR 1.45, 95% CI: 0.96-2.27), but it was not statistically significant.</p><p><strong>Conclusion: </strong>Penile HPV and HIV were highly prevalent among circumcised SMM in Nigeria. The most prevalent strains were vaccine-preventable, highlighting the need to prioritize HPV vaccination for boys as an additional strategy to prevent HPV-related morbidities.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Penile human papillomavirus prevalence in circumcised sexual minority men living with and without HIV.\",\"authors\":\"Nginache Nampota-Nkomba, Kareshma Mohanty, Ruxton Adebiyi, Charles Ekeh, Lisa M Schumaker, Kareemah T Suleiman, Laura Powell, Kara Lombardi, Nicholas P Ambulos, Elizabeth Shoyemi, Abdulwasiu B Tiamiyu, Michael G Homan, Mohammad M Sajadi, Søren M Bentzen, Kevin J Cullen, Trevor A Crowell, Rebecca G Nowak\",\"doi\":\"10.1097/QAD.0000000000004209\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Understanding the burden of penile human papillomavirus (HPV) among high-risk groups is essential to inform tailored prevention strategies to reduce HPV-related morbidity. We estimated the prevalence of penile HPV and its association with HIV among circumcised sexual minority men (SMM).</p><p><strong>Design: </strong>A cross-sectional study from a community-based cohort of SMM with and without HIV in Nigeria.</p><p><strong>Methods: </strong>Penile swabs were genotyped with a next-generation sequencing assay for any and high-risk HPV (HPV16/18/31/33/35/39/45/51/52/56/58/59/68). HIV status was ascertained using rapid diagnostic tests. Multivariable logistic regression models estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between HIV and any and high-risk penile HPV.</p><p><strong>Results: </strong>Among 498 participants, median age was 24 (interquartile range: 22-28) years and 70.5% (n = 351) were living with HIV. The prevalence of any (n = 362) and high-risk (n = 239) penile HPV was 72.7% [95% confidence interval (95% CI): 68.6-76.4] and 48.0% (95% CI: 43.6-52.4), respectively. The most common high-risk HPV types were 16, 51, 45, and 18, while the most common low-risk types were 6 and 11. HIV was significantly associated with increased odds of any penile HPV (aOR 1.93, 95% CI: 1.20-3.12). Similar to any HPV, the association of HIV with high-risk penile HPV trended in the positive direction (aOR 1.45, 95% CI: 0.96-2.27), but it was not statistically significant.</p><p><strong>Conclusion: </strong>Penile HPV and HIV were highly prevalent among circumcised SMM in Nigeria. The most prevalent strains were vaccine-preventable, highlighting the need to prioritize HPV vaccination for boys as an additional strategy to prevent HPV-related morbidities.</p>\",\"PeriodicalId\":7502,\"journal\":{\"name\":\"AIDS\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AIDS\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/QAD.0000000000004209\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/QAD.0000000000004209","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Penile human papillomavirus prevalence in circumcised sexual minority men living with and without HIV.
Objective: Understanding the burden of penile human papillomavirus (HPV) among high-risk groups is essential to inform tailored prevention strategies to reduce HPV-related morbidity. We estimated the prevalence of penile HPV and its association with HIV among circumcised sexual minority men (SMM).
Design: A cross-sectional study from a community-based cohort of SMM with and without HIV in Nigeria.
Methods: Penile swabs were genotyped with a next-generation sequencing assay for any and high-risk HPV (HPV16/18/31/33/35/39/45/51/52/56/58/59/68). HIV status was ascertained using rapid diagnostic tests. Multivariable logistic regression models estimated the adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for the association between HIV and any and high-risk penile HPV.
Results: Among 498 participants, median age was 24 (interquartile range: 22-28) years and 70.5% (n = 351) were living with HIV. The prevalence of any (n = 362) and high-risk (n = 239) penile HPV was 72.7% [95% confidence interval (95% CI): 68.6-76.4] and 48.0% (95% CI: 43.6-52.4), respectively. The most common high-risk HPV types were 16, 51, 45, and 18, while the most common low-risk types were 6 and 11. HIV was significantly associated with increased odds of any penile HPV (aOR 1.93, 95% CI: 1.20-3.12). Similar to any HPV, the association of HIV with high-risk penile HPV trended in the positive direction (aOR 1.45, 95% CI: 0.96-2.27), but it was not statistically significant.
Conclusion: Penile HPV and HIV were highly prevalent among circumcised SMM in Nigeria. The most prevalent strains were vaccine-preventable, highlighting the need to prioritize HPV vaccination for boys as an additional strategy to prevent HPV-related morbidities.
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Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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