血清β-人绒毛膜促性腺激素、雌二醇和黄体酮水平对不明原因复发性流产妇女妊娠评估的每周变化

IF 1.4 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of International Medical Research Pub Date : 2025-04-01 Epub Date: 2025-04-30 DOI:10.1177/03000605251327478
Ruide Su, Yan Wang, Ye Lu, Bizhu Lin, Jian An
{"title":"血清β-人绒毛膜促性腺激素、雌二醇和黄体酮水平对不明原因复发性流产妇女妊娠评估的每周变化","authors":"Ruide Su, Yan Wang, Ye Lu, Bizhu Lin, Jian An","doi":"10.1177/03000605251327478","DOIUrl":null,"url":null,"abstract":"<p><p>ObjectiveTo investigate the efficacy of weekly measurement of β-human chorionic gonadotropin, estradiol, and progesterone levels for pregnancy assessment in patients with unexplained recurrent miscarriage.MethodsWe retrospectively included patients with unexplained recurrent miscarriage whose serum β-human chorionic gonadotropin, estradiol, and progesterone levels were measured three or more times during early pregnancy. The patients were divided into two groups according to pregnancy outcomes. The Δβ-human chorionic gonadotropin, Δestradiol, and Δprogesterone levels of the two groups were compared, and the corresponding cutoff values were determined using receiver operating characteristic analyses for predicting pregnancy outcome.ResultsA total of 140 patients were analyzed. From the 6th week to 10th week, the serum β-human chorionic gonadotropin and estradiol levels of the ongoing pregnancy group were significantly higher than those of the miscarriage group. The serum Δβ-human chorionic gonadotropin levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.841 (95% confidence interval: 0.769-0.914) and diagnostic cutoff value of 30,633 mIU/mL. The Δestradiol levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.839 (95% confidence interval: 0.752-0.926) and a cutoff value of 45 pg/mL.ConclusionsWeekly remeasurement of serum β-human chorionic gonadotropin and estradiol may be useful for pregnancy risk assessment in patients with unexplained recurrent miscarriage in clinical practice.</p>","PeriodicalId":16129,"journal":{"name":"Journal of International Medical Research","volume":"53 4","pages":"3000605251327478"},"PeriodicalIF":1.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046155/pdf/","citationCount":"0","resultStr":"{\"title\":\"Weekly changes in serum <b>β</b>-human chorionic gonadotropin, estradiol, and progesterone levels for pregnancy assessment in women with unexplained recurrent miscarriage.\",\"authors\":\"Ruide Su, Yan Wang, Ye Lu, Bizhu Lin, Jian An\",\"doi\":\"10.1177/03000605251327478\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ObjectiveTo investigate the efficacy of weekly measurement of β-human chorionic gonadotropin, estradiol, and progesterone levels for pregnancy assessment in patients with unexplained recurrent miscarriage.MethodsWe retrospectively included patients with unexplained recurrent miscarriage whose serum β-human chorionic gonadotropin, estradiol, and progesterone levels were measured three or more times during early pregnancy. The patients were divided into two groups according to pregnancy outcomes. The Δβ-human chorionic gonadotropin, Δestradiol, and Δprogesterone levels of the two groups were compared, and the corresponding cutoff values were determined using receiver operating characteristic analyses for predicting pregnancy outcome.ResultsA total of 140 patients were analyzed. From the 6th week to 10th week, the serum β-human chorionic gonadotropin and estradiol levels of the ongoing pregnancy group were significantly higher than those of the miscarriage group. The serum Δβ-human chorionic gonadotropin levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.841 (95% confidence interval: 0.769-0.914) and diagnostic cutoff value of 30,633 mIU/mL. The Δestradiol levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.839 (95% confidence interval: 0.752-0.926) and a cutoff value of 45 pg/mL.ConclusionsWeekly remeasurement of serum β-human chorionic gonadotropin and estradiol may be useful for pregnancy risk assessment in patients with unexplained recurrent miscarriage in clinical practice.</p>\",\"PeriodicalId\":16129,\"journal\":{\"name\":\"Journal of International Medical Research\",\"volume\":\"53 4\",\"pages\":\"3000605251327478\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046155/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of International Medical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/03000605251327478\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of International Medical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03000605251327478","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/30 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0

摘要

目的探讨周测β-人绒毛膜促性腺激素、雌二醇和黄体酮水平在不明原因复发性流产患者妊娠评估中的作用。方法回顾性纳入在妊娠早期检测3次及以上血清β-人绒毛膜促性腺激素、雌二醇和黄体酮水平的不明原因复发性流产患者。根据妊娠结局将患者分为两组。比较两组患者的绒毛膜促性腺激素Δβ-human、Δestradiol和Δprogesterone水平,并通过受试者工作特征分析确定相应的截止值,预测妊娠结局。结果共分析140例患者。妊娠6 ~ 10周,妊娠持续组血清β-人绒毛膜促性腺激素和雌二醇水平显著高于流产组。血清Δβ-human绒毛膜促性腺激素水平确定正在妊娠或流产,其在受试者工作特征曲线下的面积为0.841(95%可信区间:0.769-0.914),诊断截止值为30,633 mIU/mL。Δestradiol水平确定正在怀孕或流产,接受者工作特征曲线下的面积为0.839(95%置信区间:0.752-0.926),截止值为45 pg/mL。结论每周复查血清β-人绒毛膜促性腺激素和雌二醇可用于临床不明原因复发性流产患者的妊娠风险评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Weekly changes in serum β-human chorionic gonadotropin, estradiol, and progesterone levels for pregnancy assessment in women with unexplained recurrent miscarriage.

ObjectiveTo investigate the efficacy of weekly measurement of β-human chorionic gonadotropin, estradiol, and progesterone levels for pregnancy assessment in patients with unexplained recurrent miscarriage.MethodsWe retrospectively included patients with unexplained recurrent miscarriage whose serum β-human chorionic gonadotropin, estradiol, and progesterone levels were measured three or more times during early pregnancy. The patients were divided into two groups according to pregnancy outcomes. The Δβ-human chorionic gonadotropin, Δestradiol, and Δprogesterone levels of the two groups were compared, and the corresponding cutoff values were determined using receiver operating characteristic analyses for predicting pregnancy outcome.ResultsA total of 140 patients were analyzed. From the 6th week to 10th week, the serum β-human chorionic gonadotropin and estradiol levels of the ongoing pregnancy group were significantly higher than those of the miscarriage group. The serum Δβ-human chorionic gonadotropin levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.841 (95% confidence interval: 0.769-0.914) and diagnostic cutoff value of 30,633 mIU/mL. The Δestradiol levels identified ongoing pregnancy or miscarriage with an area under the receiver operating characteristic curve of 0.839 (95% confidence interval: 0.752-0.926) and a cutoff value of 45 pg/mL.ConclusionsWeekly remeasurement of serum β-human chorionic gonadotropin and estradiol may be useful for pregnancy risk assessment in patients with unexplained recurrent miscarriage in clinical practice.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.20
自引率
0.00%
发文量
555
审稿时长
1 months
期刊介绍: _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信