{"title":"基于钌的抗癌药物RAPTA-C和Carvacrol结合的透明质酸改变脂质体用于卵巢细胞及其诱导凋亡的工程研究。","authors":"Xin Huang","doi":"10.1002/bab.2770","DOIUrl":null,"url":null,"abstract":"<p><p>Ovarian cancer (OC) is the fifth most common cancer in women, resulting in more deaths than any other female reproductive system disease. This investigation presents hyaluronic acid (HA)-altered liposome encapsulating 1,3,5-triaza-7-phosphaadamantane compound (RAP) and carvacrol (CAR) (RAP-HA@Lipo/CAR) for targeted delivery to enhance antitumor and antimetastatic efficacy in OC. The co-delivered liposomes enhanced anticancer and synergic activity in A2780 OC cells. Further, the apoptotic potential of RAP-HA@Lipo/CAR was assessed by acridine orange (AO)/propidium iodide (PI) and 4,6-diamidino-2-phenylindole dihydrochloride (DAPI)/PI staining techniques. The antimetastatic potential of RAP-HA@Lipo/CAR was evaluated using wound healing and migration assays. Our findings indicated that HA alteration enhanced the cell uptake of the developed RAP-HA@Lipo/CAR in A2780 cell lines. This study demonstrates a tumor-targeting RAP-HA@Lipo/CAR delivery promising to treat OC cells.</p>","PeriodicalId":9274,"journal":{"name":"Biotechnology and applied biochemistry","volume":" ","pages":"e2770"},"PeriodicalIF":3.2000,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Engineering of Ruthenium-Based Anticancer Drug RAPTA-C and Carvacrol Incorporated Hyaluronic Acid-Altered Liposome Formulation for Ovarian Cells and Its Apoptosis Induction.\",\"authors\":\"Xin Huang\",\"doi\":\"10.1002/bab.2770\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Ovarian cancer (OC) is the fifth most common cancer in women, resulting in more deaths than any other female reproductive system disease. This investigation presents hyaluronic acid (HA)-altered liposome encapsulating 1,3,5-triaza-7-phosphaadamantane compound (RAP) and carvacrol (CAR) (RAP-HA@Lipo/CAR) for targeted delivery to enhance antitumor and antimetastatic efficacy in OC. The co-delivered liposomes enhanced anticancer and synergic activity in A2780 OC cells. Further, the apoptotic potential of RAP-HA@Lipo/CAR was assessed by acridine orange (AO)/propidium iodide (PI) and 4,6-diamidino-2-phenylindole dihydrochloride (DAPI)/PI staining techniques. The antimetastatic potential of RAP-HA@Lipo/CAR was evaluated using wound healing and migration assays. Our findings indicated that HA alteration enhanced the cell uptake of the developed RAP-HA@Lipo/CAR in A2780 cell lines. This study demonstrates a tumor-targeting RAP-HA@Lipo/CAR delivery promising to treat OC cells.</p>\",\"PeriodicalId\":9274,\"journal\":{\"name\":\"Biotechnology and applied biochemistry\",\"volume\":\" \",\"pages\":\"e2770\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biotechnology and applied biochemistry\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1002/bab.2770\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biotechnology and applied biochemistry","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/bab.2770","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Engineering of Ruthenium-Based Anticancer Drug RAPTA-C and Carvacrol Incorporated Hyaluronic Acid-Altered Liposome Formulation for Ovarian Cells and Its Apoptosis Induction.
Ovarian cancer (OC) is the fifth most common cancer in women, resulting in more deaths than any other female reproductive system disease. This investigation presents hyaluronic acid (HA)-altered liposome encapsulating 1,3,5-triaza-7-phosphaadamantane compound (RAP) and carvacrol (CAR) (RAP-HA@Lipo/CAR) for targeted delivery to enhance antitumor and antimetastatic efficacy in OC. The co-delivered liposomes enhanced anticancer and synergic activity in A2780 OC cells. Further, the apoptotic potential of RAP-HA@Lipo/CAR was assessed by acridine orange (AO)/propidium iodide (PI) and 4,6-diamidino-2-phenylindole dihydrochloride (DAPI)/PI staining techniques. The antimetastatic potential of RAP-HA@Lipo/CAR was evaluated using wound healing and migration assays. Our findings indicated that HA alteration enhanced the cell uptake of the developed RAP-HA@Lipo/CAR in A2780 cell lines. This study demonstrates a tumor-targeting RAP-HA@Lipo/CAR delivery promising to treat OC cells.
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Published since 1979, Biotechnology and Applied Biochemistry is dedicated to the rapid publication of high quality, significant research at the interface between life sciences and their technological exploitation.
The Editors will consider papers for publication based on their novelty and impact as well as their contribution to the advancement of medical biotechnology and industrial biotechnology, covering cutting-edge research in synthetic biology, systems biology, metabolic engineering, bioengineering, biomaterials, biosensing, and nano-biotechnology.
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