靶向治疗联合一种促进癌细胞终末分化的药物。

Q3 Agricultural and Biological Sciences

Doklady Biological Sciences Pub Date : 2025-04-01 Epub Date: 2025-04-11 DOI:10.1134/S0012496624600702

E I Shramova, G M Proshkina, I N Zavestovskaya, S M Deyev

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引用次数: 0

摘要

目前，除了标准方法外，正在开发一种治疗肿瘤疾病的方法，其中通过药物诱导癌细胞的最终分化，这增加了对传统治疗方法的反应。根据文献资料，二甲基亚砜（DMSO）是一种安全的佐剂，可以刺激各种类型的癌细胞分化。本文提出了一种消除SKOV3的方法。以her2特异性毒素DARPin-LoPE为基础的靶向治疗与以DMSO为增强剂的肿瘤细胞终末分化联合治疗ip1人卵巢癌细胞腺癌。

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Targeted Therapy in Combination with an Agent That Enhances Terminal Differentiation of Cancer Cells.

Currently, in addition to standard methods, an approach is being developed for the treatment of oncological diseases in which terminal differentiation of cancer cells is induced by pharmacological drugs, which increases the response to traditional treatment methods. According to literature data, dimethyl sulfoxide (DMSO) is a safe adjuvant that stimulates the differentiation of various types of the cancer cells. A method proposed in the article was designed to eliminate SKOV3.ip1 human ovarian cancer cell adenocarcinomas by combining targeted therapy based on the HER2-specific toxin DARPin-LoPE and treatment with DMSO as an enhancing agent for terminal differentiation of cancer cells.

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来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.