利用光声超声成像在大型动物模型中评估心脏射频消融的体内效果。

IF 8 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC. Clinical electrophysiology Pub Date : 2025-05-01 DOI:10.1016/j.jacep.2025.02.031

Nilesh Mathuria MD , Krithik Vishwanath , Blake C. Fallon BA , Antonio Martino MS , Giorgio Brero MS , Richard C. Willson PhD , Miguel Valderrabano MD, PhD , Carly S. Filgueira PhD , Richard R. Bouchard PhD

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引用次数: 0

摘要

尽管导管技术的进步，术中射频消融（RFA）病变的评估仍然难以捉摸。先前的离体数据表明光声成像（PAI）可以提供RFA病变特征，但缺乏体内数据。PAI包括向组织传递近红外光，产生可被临床可用的超声换能器检测到的瞬态声波，提供基于光学的组织深度表征。在开胸猪模型中置入3个心外膜RFA病变。体内基于pai的RFA病变尺寸测量与(

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In Vivo Assessment of Cardiac Radiofrequency Ablation in a Large-Animal Model Using Photoacoustic-Ultrasound Imaging

Despite advancements in catheter technology, intraoperative assessment of radiofrequency ablation (RFA) lesions remains elusive. Prior ex vivo data suggest photoacoustic imaging (PAI) can provide RFA lesion characteristics, but in vivo data are lacking. PAI involves delivering near-infrared light to tissue, leading to transient acoustic waves that can be detected by clinically available ultrasound transducers, providing optically based tissue characterization at depth. Three epicardial RFA lesions were delivered in an open-chest porcine model. In vivo PAI-based measurements of RFA lesion dimensions matched (<0.7-mm error) gross pathologic assessment, yielding in vivo feasibility data of PAI to provide intraoperative RFA lesion dimensions.

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来源期刊

JACC. Clinical electrophysiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

10.30

自引率

5.70%

发文量

250

期刊介绍： JACC: Clinical Electrophysiology is one of a family of specialist journals launched by the renowned Journal of the American College of Cardiology (JACC). It encompasses all aspects of the epidemiology, pathogenesis, diagnosis and treatment of cardiac arrhythmias. Submissions of original research and state-of-the-art reviews from cardiology, cardiovascular surgery, neurology, outcomes research, and related fields are encouraged. Experimental and preclinical work that directly relates to diagnostic or therapeutic interventions are also encouraged. In general, case reports will not be considered for publication.