抗生素绿色替代品的多组学初步研究：白头草、枫木和丁酸梭菌对鸡肠道健康和代谢调节的影响。

IF 2.7 2区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animals Pub Date : 2025-04-29 DOI:10.3390/ani15091262

Lin Sun, Zhijun Wang, Shidi Qin, Chunhong Liang, Ayong Zhao, Ke He

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引用次数: 0

摘要

抗生素耐药性已成为一个全球性的健康问题，推动了对畜牧业可持续替代品的需求。本研究探讨了天然饲料添加剂作为一种可行的解决方案的潜力，以促进家禽生长和健康，同时减少对抗生素的依赖。中草药和益生菌作为绿色、健康、安全的抗生素替代品在畜禽生产中得到了广泛的研究。试验选用120只鸡，随机分为4组：对照组和3个添加1%白头草粉、3%鲜槭、1%丁酸梭菌的处理组。结果表明，白头草粉显著提高了γ -谷氨酰半胱氨酸（p < 0.05）、udp - n -乙酰氨基葡萄糖（p < 0.05）、酪胺（p < 0.01）和亮氨酸（p < 0.05）。槭干显著改变了盲肠代谢物，包括l -酪氨酸（p < 0.05）、α-酮异戊酸（p < 0.01）、肉豆蔻酸（p < 0.01）、谷胱甘肽（p < 0.05）和PGA1 （p < 0.05）。丁酸梭菌对盲肠代谢物如l -谷氨酰胺（p < 0.05）、核黄素（p < 0.05）、l -肉碱（p < 0.05）、麦角钙化醇（p < 0.01）和α-生育三烯醇（p < 0.05）进行了修饰。

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Preliminary Multi-Omics Insights into Green Alternatives to Antibiotics: Effects of Pulsatilla chinensis, Acer truncatum, and Clostridium butyricum on Gut Health and Metabolic Regulation in Chickens.

Antibiotic resistance has become a global health concern, driving the need for sustainable alternatives in animal husbandry. This study explores the potential of natural feed additives as a viable solution to enhance poultry growth and health while reducing reliance on antibiotics. Chinese herbal medicines and probiotics have been widely studied as green, healthy, and safe antibiotic alternatives in livestock and poultry production. A total of 120 chickens were randomly divided into four groups: a control group and three treatment groups supplemented with 1% Pulsatilla chinensis powder, 3% fresh Acer truncatum, or 1% Clostridium butyricum. The results showed that Pulsatilla chinensis powder significantly increased gamma-glutamylcysteine (p < 0.05), UDP-N-acetylglucosamine (p < 0.05), tyramine (p < 0.01), and leucine (p < 0.05). Acer truncatum notably altered cecal metabolites, including L-tyrosine (p < 0.05), α-ketoisovaleric acid (p < 0.01), myristoleic acid (p < 0.01), glutathione (p < 0.05), and PGA1 (p < 0.05). Clostridium butyricum modified cecal metabolites such as L-glutamine (p < 0.05), riboflavin (p < 0.05), L-Carnitine (p < 0.05), ergocalciferol (p < 0.01), and α-tocotrienol (p < 0.05).

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来源期刊

Animals Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

4.90

自引率

16.70%

发文量

3015

审稿时长

20.52 days

期刊介绍： Animals (ISSN 2076-2615) is an international and interdisciplinary scholarly open access journal. It publishes original research articles, reviews, communications, and short notes that are relevant to any field of study that involves animals, including zoology, ethnozoology, animal science, animal ethics and animal welfare. However, preference will be given to those articles that provide an understanding of animals within a larger context (i.e., the animals'' interactions with the outside world, including humans). There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental details and/or method of study, must be provided for research articles. Articles submitted that involve subjecting animals to unnecessary pain or suffering will not be accepted, and all articles must be submitted with the necessary ethical approval (please refer to the Ethical Guidelines for more information).