{"title":"显微混浊介质持久同源光学性质的真实光传播分析。","authors":"Jirawit Jiracheewee, Yu Shimojo, Takahiro Nishimura","doi":"10.1364/BOE.557290","DOIUrl":null,"url":null,"abstract":"<p><p>The optical properties of microscopic turbid media are critical for understanding light-tissue interactions with applications in biomedical imaging and diagnostics. However, traditional scattering coefficient-based methods are limited in their ability to capture topological heterogeneities within tissue structures, which play a crucial role in describing the relationship between microscopic tissue characteristics and their corresponding light propagation behaviors. In this study, we propose using persistent homology-based persistent images (PIs) as a descriptor and optical property of microscopic tissues. As a proof of concept, we analyzed particle-distributed turbid media with uniform and clustered particle distributions by persistent homology analysis, demonstrating that PIs can capture topological characteristics that are not discernible using traditional scattering coefficient-based methods. Light propagation simulations using the beam propagation method (BPM) demonstrated that PIs correlate with optical behaviors, such as beam centroid displacement and distortion, providing a foundation for linking microscopic topological heterogeneities to light propagation behaviors. Our results validate PIs as a meaningful and predictive optical property, bridging microscopic turbid media topology with their light propagation behaviors. This work establishes PIs as a potential optical property of microscopic tissue, capturing its topological characteristics and offering predictive insights into light propagation behaviors.</p>","PeriodicalId":8969,"journal":{"name":"Biomedical optics express","volume":"16 4","pages":"1651-1665"},"PeriodicalIF":2.9000,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047721/pdf/","citationCount":"0","resultStr":"{\"title\":\"Persistent homology-based optical properties of microscopic turbid media for realistic light propagation analysis.\",\"authors\":\"Jirawit Jiracheewee, Yu Shimojo, Takahiro Nishimura\",\"doi\":\"10.1364/BOE.557290\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The optical properties of microscopic turbid media are critical for understanding light-tissue interactions with applications in biomedical imaging and diagnostics. However, traditional scattering coefficient-based methods are limited in their ability to capture topological heterogeneities within tissue structures, which play a crucial role in describing the relationship between microscopic tissue characteristics and their corresponding light propagation behaviors. In this study, we propose using persistent homology-based persistent images (PIs) as a descriptor and optical property of microscopic tissues. As a proof of concept, we analyzed particle-distributed turbid media with uniform and clustered particle distributions by persistent homology analysis, demonstrating that PIs can capture topological characteristics that are not discernible using traditional scattering coefficient-based methods. Light propagation simulations using the beam propagation method (BPM) demonstrated that PIs correlate with optical behaviors, such as beam centroid displacement and distortion, providing a foundation for linking microscopic topological heterogeneities to light propagation behaviors. Our results validate PIs as a meaningful and predictive optical property, bridging microscopic turbid media topology with their light propagation behaviors. This work establishes PIs as a potential optical property of microscopic tissue, capturing its topological characteristics and offering predictive insights into light propagation behaviors.</p>\",\"PeriodicalId\":8969,\"journal\":{\"name\":\"Biomedical optics express\",\"volume\":\"16 4\",\"pages\":\"1651-1665\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-03-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047721/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical optics express\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1364/BOE.557290\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical optics express","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1364/BOE.557290","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
Persistent homology-based optical properties of microscopic turbid media for realistic light propagation analysis.
The optical properties of microscopic turbid media are critical for understanding light-tissue interactions with applications in biomedical imaging and diagnostics. However, traditional scattering coefficient-based methods are limited in their ability to capture topological heterogeneities within tissue structures, which play a crucial role in describing the relationship between microscopic tissue characteristics and their corresponding light propagation behaviors. In this study, we propose using persistent homology-based persistent images (PIs) as a descriptor and optical property of microscopic tissues. As a proof of concept, we analyzed particle-distributed turbid media with uniform and clustered particle distributions by persistent homology analysis, demonstrating that PIs can capture topological characteristics that are not discernible using traditional scattering coefficient-based methods. Light propagation simulations using the beam propagation method (BPM) demonstrated that PIs correlate with optical behaviors, such as beam centroid displacement and distortion, providing a foundation for linking microscopic topological heterogeneities to light propagation behaviors. Our results validate PIs as a meaningful and predictive optical property, bridging microscopic turbid media topology with their light propagation behaviors. This work establishes PIs as a potential optical property of microscopic tissue, capturing its topological characteristics and offering predictive insights into light propagation behaviors.
期刊介绍:
The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including:
Tissue optics and spectroscopy
Novel microscopies
Optical coherence tomography
Diffuse and fluorescence tomography
Photoacoustic and multimodal imaging
Molecular imaging and therapies
Nanophotonic biosensing
Optical biophysics/photobiology
Microfluidic optical devices
Vision research.