Rory J Lubner, Mason Krysinski, Ping Li, Rakesh K Chandra, Justin H Turner, Naweed I Chowdhury
{"title":"长期颗粒物暴露可能增加慢性鼻窦炎伴鼻息肉病的风险：一项暴露匹配研究的结果","authors":"Rory J Lubner, Mason Krysinski, Ping Li, Rakesh K Chandra, Justin H Turner, Naweed I Chowdhury","doi":"10.1002/alr.23589","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Particulate matter ⩽2.5 µm in diameter (PM<sub>2.5</sub>) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM<sub>2.5</sub> exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway. However, there are limited data comparing cytokine changes in CRS sinonasal tissue to non-CRS patients as it relates to PM<sub>2.5</sub> exposure. We hypothesized that long-term exposure preferentially increases the risk of manifesting CRS with nasal polyposis (CRSwNP).</p><p><strong>Methods: </strong>We performed a retrospective analysis of 376 patients (308 CRS, 68 controls) who underwent endoscopic sinus or skull base surgery. A spatiotemporal machine-learning model estimated daily PM<sub>2.5</sub> levels for 1 year prior to each patient's surgery date. Cytokines were quantified using a multiplex flow cytometric bead assay and compared to estimated PM<sub>2.5</sub> exposure using Spearman correlation and multivariate regression. Patients with high and low 12-month PM<sub>2.5</sub> exposures were matched across age, sex, income, and rurality using a nearest neighbor algorithm. Multivariate adjusted logistic regression was used to estimate the odds of CRS based on PM<sub>2.5</sub> exposure.</p><p><strong>Results: </strong>Reduced IL-10 levels were associated with higher PM<sub>2.5</sub> exposures in control patients (β = -0.735, p = 0.0196). In exposure-matched logistic regression analysis, high 12-month PM<sub>2.5</sub> exposure was an independent predictor of CRSwNP (β = 1.97, OR: 7.22, p = 0.0001) after adjustment for age, income, rurality, and comorbid asthma/allergic rhinitis. A similar relationship was not identified for CRSsNP.</p><p><strong>Conclusions: </strong>PM<sub>2.5</sub> exposure is associated with reduced IL-10 in control patients compared to CRS and may increase odds of CRSwNP development.</p>","PeriodicalId":13716,"journal":{"name":"International Forum of Allergy & Rhinology","volume":" ","pages":"e23589"},"PeriodicalIF":7.2000,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-Term Particulate Matter Exposure May Increase Risk of Chronic Rhinosinusitis WIth Nasal Polyposis: Results from an Exposure-Matched Study.\",\"authors\":\"Rory J Lubner, Mason Krysinski, Ping Li, Rakesh K Chandra, Justin H Turner, Naweed I Chowdhury\",\"doi\":\"10.1002/alr.23589\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Particulate matter ⩽2.5 µm in diameter (PM<sub>2.5</sub>) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM<sub>2.5</sub> exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway. However, there are limited data comparing cytokine changes in CRS sinonasal tissue to non-CRS patients as it relates to PM<sub>2.5</sub> exposure. We hypothesized that long-term exposure preferentially increases the risk of manifesting CRS with nasal polyposis (CRSwNP).</p><p><strong>Methods: </strong>We performed a retrospective analysis of 376 patients (308 CRS, 68 controls) who underwent endoscopic sinus or skull base surgery. A spatiotemporal machine-learning model estimated daily PM<sub>2.5</sub> levels for 1 year prior to each patient's surgery date. Cytokines were quantified using a multiplex flow cytometric bead assay and compared to estimated PM<sub>2.5</sub> exposure using Spearman correlation and multivariate regression. Patients with high and low 12-month PM<sub>2.5</sub> exposures were matched across age, sex, income, and rurality using a nearest neighbor algorithm. Multivariate adjusted logistic regression was used to estimate the odds of CRS based on PM<sub>2.5</sub> exposure.</p><p><strong>Results: </strong>Reduced IL-10 levels were associated with higher PM<sub>2.5</sub> exposures in control patients (β = -0.735, p = 0.0196). In exposure-matched logistic regression analysis, high 12-month PM<sub>2.5</sub> exposure was an independent predictor of CRSwNP (β = 1.97, OR: 7.22, p = 0.0001) after adjustment for age, income, rurality, and comorbid asthma/allergic rhinitis. 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引用次数: 0
摘要
背景：直径≥2.5µm的颗粒物（PM2.5）及其在慢性鼻窦炎（CRS）发病机制中的作用已引起人们的高度关注。我们之前证明PM2.5暴露可能使CRS的鼻黏膜偏向2型炎症途径。然而，比较CRS患者与非CRS患者鼻窦组织中细胞因子变化与PM2.5暴露的关系的数据有限。我们假设长期暴露优先增加CRS合并鼻息肉病（CRSwNP）的风险。方法：我们对376例接受鼻内镜或颅底手术的患者（308例CRS， 68例对照组）进行回顾性分析。一个时空机器学习模型估计了每位患者手术日期前一年的每日PM2.5水平。使用多重流式细胞术测定细胞因子，并使用Spearman相关和多变量回归与估计的PM2.5暴露量进行比较。使用最近邻算法对12个月PM2.5暴露量高低的患者进行年龄、性别、收入和农村地区的匹配。采用多因素调整logistic回归估计PM2.5暴露导致CRS的几率。结果：对照组患者IL-10水平降低与PM2.5暴露水平升高相关（β = -0.735, p = 0.0196）。在暴露匹配的logistic回归分析中，在调整了年龄、收入、农村状况和合并症哮喘/变应性鼻炎后，12个月的高PM2.5暴露是CRSwNP的独立预测因子（β = 1.97, OR: 7.22, p = 0.0001）。crsssnp没有发现类似的关系。结论：与CRS相比，PM2.5暴露与对照患者IL-10降低有关，并可能增加CRSwNP发展的几率。
Long-Term Particulate Matter Exposure May Increase Risk of Chronic Rhinosinusitis WIth Nasal Polyposis: Results from an Exposure-Matched Study.
Background: Particulate matter ⩽2.5 µm in diameter (PM2.5) and its role in chronic rhinosinusitis (CRS) pathogenesis have gained heightened attention. We previously demonstrated that PM2.5 exposure may bias the nasal mucosa in CRS toward a Type 2 inflammatory pathway. However, there are limited data comparing cytokine changes in CRS sinonasal tissue to non-CRS patients as it relates to PM2.5 exposure. We hypothesized that long-term exposure preferentially increases the risk of manifesting CRS with nasal polyposis (CRSwNP).
Methods: We performed a retrospective analysis of 376 patients (308 CRS, 68 controls) who underwent endoscopic sinus or skull base surgery. A spatiotemporal machine-learning model estimated daily PM2.5 levels for 1 year prior to each patient's surgery date. Cytokines were quantified using a multiplex flow cytometric bead assay and compared to estimated PM2.5 exposure using Spearman correlation and multivariate regression. Patients with high and low 12-month PM2.5 exposures were matched across age, sex, income, and rurality using a nearest neighbor algorithm. Multivariate adjusted logistic regression was used to estimate the odds of CRS based on PM2.5 exposure.
Results: Reduced IL-10 levels were associated with higher PM2.5 exposures in control patients (β = -0.735, p = 0.0196). In exposure-matched logistic regression analysis, high 12-month PM2.5 exposure was an independent predictor of CRSwNP (β = 1.97, OR: 7.22, p = 0.0001) after adjustment for age, income, rurality, and comorbid asthma/allergic rhinitis. A similar relationship was not identified for CRSsNP.
Conclusions: PM2.5 exposure is associated with reduced IL-10 in control patients compared to CRS and may increase odds of CRSwNP development.
期刊介绍：
International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy.
International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.
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