Optical Coherence Tomography Findings in Spontaneous Full-thickness Macular Hole Closure.

Abstract: Spontaneous closure (SC) of a macular hole (MH) is a rare but well-documented phenomenon, particularly in small, early-stage holes. The exact mechanisms underlying SC remain unclear, but it is hypothesized to involve the interplay of vitreoretinal dynamics, glial cell proliferation, and the natural healing processes of the retina. Our study reports clinical features of two cases of full-thickness MHs (FTMHs) that closed spontaneously under different circumstances, as well as their optical coherence tomography (OCT) characteristics and effect on visual acuity, thus emphasizing the role of OCT in understanding this uncommon event. By documenting this rare outcome, we aim to contribute to the growing body of knowledge on FTMH and the potential for nonsurgical resolution in certain cases.