{"title":"多区域序列性疼痛综合征。","authors":"Xiao Yang, Kai-Jun Zhao, Jian-Min Liu","doi":"10.3389/fneur.2025.1553455","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To report a novel clinical entity, \"Multi-regional Sequential Pain Syndrome\" (MRSPS), and evaluate the relationship between hypoperfusion, cryptogenic vertebral artery dissection (CVAD), and MRSPS.</p><p><strong>Methods: </strong>A 59-year-old female patient, with a chronic MRSPS condition spanning 10-30 years, underwent a comprehensive diagnostic evaluation including cranial CTA, MRI, DSA, and CT perfusion, culminating in the identification of CVAD via dynamic contrast-enhanced computed tomography (DCE-CT). The treatment strategy integrated repairing CVADs with stent implantation to address the hypoperfusion and MRSPS.</p><p><strong>Results: </strong>Following intervention, hypoperfusion achieved complete improvement, and the patient achieved the complete resolution of pain and vertigo, with the modified Rankin Scale (mRS) score of 0 at the 1-year follow-up, signifying full neurological recovery.</p><p><strong>Conclusion: </strong>CVADs, a key cause of brain tissue hypoperfusion in MRSPS, can be effectively treated by repair to alleviate the syndrome.</p>","PeriodicalId":12575,"journal":{"name":"Frontiers in Neurology","volume":"16 ","pages":"1553455"},"PeriodicalIF":2.7000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066274/pdf/","citationCount":"0","resultStr":"{\"title\":\"Multi-regional sequential pain syndrome.\",\"authors\":\"Xiao Yang, Kai-Jun Zhao, Jian-Min Liu\",\"doi\":\"10.3389/fneur.2025.1553455\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To report a novel clinical entity, \\\"Multi-regional Sequential Pain Syndrome\\\" (MRSPS), and evaluate the relationship between hypoperfusion, cryptogenic vertebral artery dissection (CVAD), and MRSPS.</p><p><strong>Methods: </strong>A 59-year-old female patient, with a chronic MRSPS condition spanning 10-30 years, underwent a comprehensive diagnostic evaluation including cranial CTA, MRI, DSA, and CT perfusion, culminating in the identification of CVAD via dynamic contrast-enhanced computed tomography (DCE-CT). The treatment strategy integrated repairing CVADs with stent implantation to address the hypoperfusion and MRSPS.</p><p><strong>Results: </strong>Following intervention, hypoperfusion achieved complete improvement, and the patient achieved the complete resolution of pain and vertigo, with the modified Rankin Scale (mRS) score of 0 at the 1-year follow-up, signifying full neurological recovery.</p><p><strong>Conclusion: </strong>CVADs, a key cause of brain tissue hypoperfusion in MRSPS, can be effectively treated by repair to alleviate the syndrome.</p>\",\"PeriodicalId\":12575,\"journal\":{\"name\":\"Frontiers in Neurology\",\"volume\":\"16 \",\"pages\":\"1553455\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066274/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Neurology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fneur.2025.1553455\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fneur.2025.1553455","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Objective: To report a novel clinical entity, "Multi-regional Sequential Pain Syndrome" (MRSPS), and evaluate the relationship between hypoperfusion, cryptogenic vertebral artery dissection (CVAD), and MRSPS.
Methods: A 59-year-old female patient, with a chronic MRSPS condition spanning 10-30 years, underwent a comprehensive diagnostic evaluation including cranial CTA, MRI, DSA, and CT perfusion, culminating in the identification of CVAD via dynamic contrast-enhanced computed tomography (DCE-CT). The treatment strategy integrated repairing CVADs with stent implantation to address the hypoperfusion and MRSPS.
Results: Following intervention, hypoperfusion achieved complete improvement, and the patient achieved the complete resolution of pain and vertigo, with the modified Rankin Scale (mRS) score of 0 at the 1-year follow-up, signifying full neurological recovery.
Conclusion: CVADs, a key cause of brain tissue hypoperfusion in MRSPS, can be effectively treated by repair to alleviate the syndrome.
期刊介绍：
The section Stroke aims to quickly and accurately publish important experimental, translational and clinical studies, and reviews that contribute to the knowledge of stroke, its causes, manifestations, diagnosis, and management.
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