血浆瞬时受体电位香草素1作为急性心肌梗死的新生物标志物。

IF 1.9 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiology Pub Date : 2025-04-22 DOI:10.1159/000545901
Yong Wu, Yahao Zhang
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引用次数: 0

摘要

目的:探讨血浆瞬时受体电位香草样蛋白1 (TRPV1)水平在急性心肌梗死(AMI)患者中的诊断意义,并评价其预后价值。方法:选取中大医院2023年5月至2024年3月诊断为AMI的152例患者作为AMI组,62例非AMI患者作为对照组。入院时采用酶联免疫吸附试验(ELISA)测定血浆TRPV1水平。所有AMI患者随访6个月。结果:AMI组血浆TRPV1水平明显高于对照组(p结论:血浆TRPV1是一种很有前景的AMI诊断生物标志物,与肾功能和血糖控制有潜在联系。此外,TRPV1对预测AMI后6个月内的MACE具有预后价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma Levels of Transient Receptor Potential Vanilloid 1 as a Novel Biomarker for Acute Myocardial Infarction.

Objective: This study aims to investigate the diagnostic significance of plasma transient receptor potential vanilloid 1 (TRPV1) levels in patients with acute myocardial infarction (AMI) and to evaluate its prognostic value.

Methods: A total of 152 patients diagnosed with AMI at Zhongda Hospital between May 2023 and March 2024, forming the AMI group, along with 62 non-AMI patients as the control group. Plasma TRPV1 levels were measured using enzyme-linked immunosorbent assay (ELISA) upon admission. All patients with AMI were followed up for six months.

Results: Plasma TRPV1 levels were significantly higher in the AMI group compared to the control group (p <0.05). Pearson correlation analysis demonstrated that TRPV1 levels positively correlated with diabetes, lactate dehydrogenase (LDH), white blood cell count, creatine kinase, blood urea nitrogen (BUN), serum creatinine (Scr), glycated hemoglobin (HbA1c), brain natriuretic peptide (BNP), cardiac troponin I (cTnI), Gensini scores, and the number of affected vessels, while showing a negative correlation with hemoglobin and left ventricular ejection fraction (LVEF). Multiple linear regression analysis identified LDH, Scr, and HbA1c as independent factors influencing TRPV1 levels. Receiver operating characteristic (ROC) curve analysis demonstrated a significant diagnostic value of TRPV1 for AMI (p <0.001). Furthermore, Cox regression analysis revealed that elevated TRPV1 levels were significantly associated with the occurrence of major adverse cardiac events (MACE) within six months (p <0.001).

Conclusion: Plasma TRPV1 is a promising biomarker for the diagnosis of AMI, with potential links to renal function and glycemic control. Additionally, TRPV1 holds prognostic value for predicting MACE within six months following AMI.

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来源期刊
Cardiology
Cardiology 医学-心血管系统
CiteScore
3.40
自引率
5.30%
发文量
56
审稿时长
1.5 months
期刊介绍: ''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.
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