痣相关性原位黑色素瘤的回顾性研究。

IF 3 3区医学 Q2 DERMATOLOGY

Dermatology Pub Date : 2025-05-05 DOI:10.1159/000546226

Clio Dessinioti, Angelliki Befon, Mihaella Plaka, Aikaterini Niforou, Katerina Kypreou, Electra Nicolaidou, Antonina Lingria, Alexander Stratigos

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引用次数: 0

摘要

在原位黑色素瘤（MIS）的组织学中，痣关联的频率和类型尚不清楚。方法：我们进行了回顾性研究，探讨组织学（常见或发育不良）的MIS相邻痣的特征、频率和类型。排除恶性Lentigo （LM）和原位肢端lentiginous melanomas （ALM）。结果：1991 ~ 2023年，共有448例非恶性青光体/非alm MIS可用。353例（79%）为痣相关性MIS （NAM-MIS）。在这些病例中，326例NAM-MIS（94%）有发育不良的痣残余。在发育不良痣- mis中，176例（54%）伴有严重发育不良痣。痣相关的MIS与新生MIS更常位于躯干（54%对36%），较少位于头颈部（8%对11%）（p=0.02）。结论：痣相关性是MIS的常见发现，几乎所有的痣相关性MIS都与发育不良的痣有关。这些发现可能表明从严重发育不良痣到MIS的进化，也反映了相同的组织病理学分类，并支持了它们之前提出的生物等效性，不是侵袭性黑色素瘤的必要前体。

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A retrospective study of nevus-associated melanoma in situ.

Introduction: The frequency and type of nevus association in histology in melanoma in situ (MIS) is unclear.

Methods: We performed a retrospective study to investigate the characteristics, frequency and type of adjacent nevus in histology (common or dysplastic) in MIS. Lentigo maligna (LM) and in situ acral lentiginous melanomas (ALM) were excluded.

Results: From 1991 to 2023, there were 448 available non-lentigo maligna/non-ALM MIS. MIS were nevus-associated (NAM-MIS) in 353 cases (79%). Of these cases, 326 NAM-MIS (94%) had dysplastic nevus remnants. Among the dysplastic nevus-MIS, 176 (54%) were adjacent with severely dysplastic nevus. Nevus-associated MIS vs de novo MIS were more frequently located on the trunk (54% vs 36%), and less frequently located on the head/neck (8% vs 11%) (p=0.02).

Conclusions: Nevus association is a common finding in MIS and almost all of nevus-associated MIS were associated with a dysplastic nevus. These findings may indicate an evolution from severely dysplastic nevus to MIS, and also reflect the equivalent histopathological classification and support their previously proposed biological equivalence as not obligate precursors of invasive melanomas.

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来源期刊

Dermatology 医学-皮肤病学

CiteScore

6.40

自引率

2.90%

发文量

审稿时长

1 months

期刊介绍： Published since 1893, ''Dermatology'' provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, editorials and reviews prepared by invited, internationally recognized scientists are regularly featured. In addition to original papers, the journal publishes rapid communications, short communications, and letters to ''Dermatology''. ''Dermatology'' answers the complete information needs of practitioners concerned with progress in research related to skin, clinical dermatology and therapy. The journal enjoys a high scientific reputation with a continually increasing impact factor and an equally high circulation.