Aishwarya Palorath, Claire Narang, Lourdes Forster, Oneith Cadiz, Amber Langshaw, Amanda Fifi, Alan Delamater, Amber N Balda, Samantha Arrizabalo, Miguel Saps
{"title":"急性胃肠炎是儿童肠脑相互作用障碍发展的危险因素。","authors":"Aishwarya Palorath, Claire Narang, Lourdes Forster, Oneith Cadiz, Amber Langshaw, Amanda Fifi, Alan Delamater, Amber N Balda, Samantha Arrizabalo, Miguel Saps","doi":"10.14309/ajg.0000000000003477","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Acute gastroenteritis (AGE) is the most common disease predisposing to the development of disorders of gut-brain interactions (DGBIs) in adults (postinfectious DGBI [PI-DGBI]). There is paucity of data on incidence and risk factors for the development of PI-DGBI in children. The aims of this study are to (i) assess whether AGE predisposes children to the development of PI-DGBI and (ii) assess whether the severity of AGE is associated with the development of PI-DGBI.</p><p><strong>Methods: </strong>This was a prospective, controlled, cohort study. Children with recent AGE (cases) and siblings (controls) were followed for 6 months. We assessed DGBIs using a validated questionnaire (QPGS IV) per Rome criteria.</p><p><strong>Results: </strong>Forty-nine cases and 55 controls were enrolled; 4 cases (8.1%) and 1 control (1.8%) had a previous diagnosis of DGBI. At 3 months, 10 cases (20.4%) were diagnosed with DGBI vs 1 (1.8%) control ( P = 0.00). Among children without a history of DGBI before the AGE, 6 (12.2%) cases vs 0 control were diagnosed with DGBI ( P = 0.01) at follow-up. At 6 months, 5 cases (1 lost to follow-up) vs 0 control had persistent DGBI ( P = 0.03). Severity of AGE was correlated with PI-DGBI (ρ = 0.707, P = 0.00).</p><p><strong>Discussion: </strong>Children with AGE are more likely to develop DGBIs compared with controls. AGE symptom severity is associated with PI-DGBI.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute Gastroenteritis Is a Risk Factor for the Development of Disorders of Gut-Brain Interaction in Children.\",\"authors\":\"Aishwarya Palorath, Claire Narang, Lourdes Forster, Oneith Cadiz, Amber Langshaw, Amanda Fifi, Alan Delamater, Amber N Balda, Samantha Arrizabalo, Miguel Saps\",\"doi\":\"10.14309/ajg.0000000000003477\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Acute gastroenteritis (AGE) is the most common disease predisposing to the development of disorders of gut-brain interactions (DGBIs) in adults (postinfectious DGBI [PI-DGBI]). There is paucity of data on incidence and risk factors for the development of PI-DGBI in children. The aims of this study are to (i) assess whether AGE predisposes children to the development of PI-DGBI and (ii) assess whether the severity of AGE is associated with the development of PI-DGBI.</p><p><strong>Methods: </strong>This was a prospective, controlled, cohort study. Children with recent AGE (cases) and siblings (controls) were followed for 6 months. We assessed DGBIs using a validated questionnaire (QPGS IV) per Rome criteria.</p><p><strong>Results: </strong>Forty-nine cases and 55 controls were enrolled; 4 cases (8.1%) and 1 control (1.8%) had a previous diagnosis of DGBI. At 3 months, 10 cases (20.4%) were diagnosed with DGBI vs 1 (1.8%) control ( P = 0.00). Among children without a history of DGBI before the AGE, 6 (12.2%) cases vs 0 control were diagnosed with DGBI ( P = 0.01) at follow-up. At 6 months, 5 cases (1 lost to follow-up) vs 0 control had persistent DGBI ( P = 0.03). Severity of AGE was correlated with PI-DGBI (ρ = 0.707, P = 0.00).</p><p><strong>Discussion: </strong>Children with AGE are more likely to develop DGBIs compared with controls. 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Acute Gastroenteritis Is a Risk Factor for the Development of Disorders of Gut-Brain Interaction in Children.
Introduction: Acute gastroenteritis (AGE) is the most common disease predisposing to the development of disorders of gut-brain interactions (DGBIs) in adults (postinfectious DGBI [PI-DGBI]). There is paucity of data on incidence and risk factors for the development of PI-DGBI in children. The aims of this study are to (i) assess whether AGE predisposes children to the development of PI-DGBI and (ii) assess whether the severity of AGE is associated with the development of PI-DGBI.
Methods: This was a prospective, controlled, cohort study. Children with recent AGE (cases) and siblings (controls) were followed for 6 months. We assessed DGBIs using a validated questionnaire (QPGS IV) per Rome criteria.
Results: Forty-nine cases and 55 controls were enrolled; 4 cases (8.1%) and 1 control (1.8%) had a previous diagnosis of DGBI. At 3 months, 10 cases (20.4%) were diagnosed with DGBI vs 1 (1.8%) control ( P = 0.00). Among children without a history of DGBI before the AGE, 6 (12.2%) cases vs 0 control were diagnosed with DGBI ( P = 0.01) at follow-up. At 6 months, 5 cases (1 lost to follow-up) vs 0 control had persistent DGBI ( P = 0.03). Severity of AGE was correlated with PI-DGBI (ρ = 0.707, P = 0.00).
Discussion: Children with AGE are more likely to develop DGBIs compared with controls. AGE symptom severity is associated with PI-DGBI.
期刊介绍：
Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.
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