随访36个月新生血管性年龄相关性黄斑变性患者视网膜内液光密度比与视力的关系

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2025-04-15 DOI:10.1038/s41433-025-03792-4

Nir Stanescu, Khaled Khalifa, Roee Arnon, Gilad Rabina, Arie Y Nemet, Itamar Arbel, Noa Geffen, Ori Segal

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引用次数: 0

摘要

目的：探讨视网膜内液（IRF）光密度比（ODR）对抗血管内皮生长因子（VEGF）治疗的新生血管性年龄相关性黄斑变性（nAMD）患者最佳矫正视力（deltaBCVA）的预后意义。方法：在本回顾性研究中，回顾了光学相干断层扫描（OCT） treatment-naïve眼抗vegf注射治疗的nAMD。在每张OCT图像中，采用严格而灵活的方法计算视网膜液室的ODR。我们采用线性混合模型研究随访36个月后OCT的ODR值与deltaBCVA的关系。结果：纳入78例患者86只眼。我们发现严格ODR与IRF之间呈负相关(p = 0.02；系数。-0.05, 95% CI -0.10, -0.01)和IRF的灵活ODR (p = 0.03；系数。-0.05, 95% CI -0.10, -0.01)， 36个月后deltaBCVA。SRF和PED的ODR与deltaBCVA无显著相关。结论：这是迄今为止最大的研究nAMD患者ODR与deltaBCVA之间关系的研究。在36个月的随访中，IRF ODR值较高的眼睛BCVA恶化的可能性较小。ODR可作为nAMD患者BCVA的另一种OCT预后生物标志物。

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The association between optical density ratio of intraretinal fluid and visual acuity in neovascular age related macular degeneration after 36 months of follow up.

Objective: To investigate the prognostic significance of optical density ratio (ODR) of intraretinal fluid (IRF) on best corrected visual acuity (deltaBCVA) in patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) agents.

Methods: In this retrospective study, optical coherence tomography (OCT) scans of treatment-naïve eyes with nAMD treated with anti-VEGF injections were reviewed. ODR of retinal fluid compartments was calculated using strict and flexible methods in each OCT image. We used linear mixed models to investigate the relationship between ODR values on OCT and deltaBCVA after 36 months of follow up.

Results: We included 86 eyes of 78 patients. We found negative associations between strict ODR of IRF (p = 0.02; coef. -0.05, 95% CI -0.10, -0.01), and flexible ODR of IRF (p = 0.03; coef. -0.05, 95% CI -0.10, -0.01), and deltaBCVA after 36 months. ODR of SRF and PED were not significantly associated with deltaBCVA.

Conclusion: This is the largest study to investigate the relationship between ODR in nAMD patients and deltaBCVA. Eyes with higher ODR values of IRF are less likely to have a deterioration in BCVA over 36 months of follow up. ODR could be used as another OCT prognostic biomarker for BCVA in nAMD patients.

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.