非洲耐克拉霉素幽门螺杆菌:系统回顾和荟萃分析。

IF 4.4 2区 医学 Q1 INFECTIOUS DISEASES
Komla Mawunyo Dossouvi, Tchilabalo Bouyo, Simon Sognonnou, Ephraim Ehidiamen Ibadin, Lu-Chao Lv, Bissoume Sambe Ba, Abdoulaye Seck, Sika Dossim, Fábio Parra Sellera, Makhtar Camara, Amr El Kelish, Stella Ifeanyi Smith
{"title":"非洲耐克拉霉素幽门螺杆菌:系统回顾和荟萃分析。","authors":"Komla Mawunyo Dossouvi, Tchilabalo Bouyo, Simon Sognonnou, Ephraim Ehidiamen Ibadin, Lu-Chao Lv, Bissoume Sambe Ba, Abdoulaye Seck, Sika Dossim, Fábio Parra Sellera, Makhtar Camara, Amr El Kelish, Stella Ifeanyi Smith","doi":"10.1186/s13756-025-01533-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In 2022, approximately 56.5% of adults and 47.1% of children and adolescents were affected by Helicobacter pylori (H. pylori) infection in Africa, and clarithromycin-resistant H. pylori (CRHp) strains have become global priority pathogens. Therefore, this study aimed to conduct the first comprehensive systematic review and meta-analysis of CRHp in Africa.</p><p><strong>Methods: </strong>This investigation was conducted according to the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (The PRISMA 2020). Literature search of electronic databases (Google Scholar, African Journals Online, ResearchGate, PubMed, Embase, and Scopus) was performed using keywords \"clarithromycin\", \"Helicobacter pylori\", \"African country name\", \"mutation in the 23S rRNA\".</p><p><strong>Results: </strong>Sixty-five studies involving 5,313 H. pylori strains isolated over 26 years (1997-2022) from 23 African countries were included in this study. The samples from which CRHp was isolated included gastric biopsy (60/63; 95%), and stool (4/63; 6%). The pooled prevalence of CRHp in Africa was 27% (95% CI: 22, 33). There was a steady trend in the prevalence of CRHp isolated in Africa over the 26 years (R<sup>2</sup> = 0.0001, p = 0.92, slope coefficient of -0.05x). Ten types of 23S rRNA mutations (conferring clarithromycin resistance) were identified, and included mainly A2143G (465 H. pylori strains out of 1178 tested) and A2142G (344 H. pylori strains out of 1027).</p><p><strong>Conclusion: </strong>To enhance the accuracy and validity of surveillance data for H. pylori in Africa, there is an urgent need for implementing standardized microbiological methods for resistance detection. The prevalence of CRHp reported in this study was very similar to the overall global prevalence and there is a need for more representative studies on CRHp in Africa. While waiting for this, the treatment of H. pylori infections must be based on the guidelines of the AHMSG first Lagos consensus.</p>","PeriodicalId":7950,"journal":{"name":"Antimicrobial Resistance and Infection Control","volume":"14 1","pages":"31"},"PeriodicalIF":4.4000,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993951/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clarithromycin-resistant Helicobacter pylori in Africa: a systematic review and meta-analysis.\",\"authors\":\"Komla Mawunyo Dossouvi, Tchilabalo Bouyo, Simon Sognonnou, Ephraim Ehidiamen Ibadin, Lu-Chao Lv, Bissoume Sambe Ba, Abdoulaye Seck, Sika Dossim, Fábio Parra Sellera, Makhtar Camara, Amr El Kelish, Stella Ifeanyi Smith\",\"doi\":\"10.1186/s13756-025-01533-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In 2022, approximately 56.5% of adults and 47.1% of children and adolescents were affected by Helicobacter pylori (H. pylori) infection in Africa, and clarithromycin-resistant H. pylori (CRHp) strains have become global priority pathogens. Therefore, this study aimed to conduct the first comprehensive systematic review and meta-analysis of CRHp in Africa.</p><p><strong>Methods: </strong>This investigation was conducted according to the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (The PRISMA 2020). Literature search of electronic databases (Google Scholar, African Journals Online, ResearchGate, PubMed, Embase, and Scopus) was performed using keywords \\\"clarithromycin\\\", \\\"Helicobacter pylori\\\", \\\"African country name\\\", \\\"mutation in the 23S rRNA\\\".</p><p><strong>Results: </strong>Sixty-five studies involving 5,313 H. pylori strains isolated over 26 years (1997-2022) from 23 African countries were included in this study. The samples from which CRHp was isolated included gastric biopsy (60/63; 95%), and stool (4/63; 6%). The pooled prevalence of CRHp in Africa was 27% (95% CI: 22, 33). There was a steady trend in the prevalence of CRHp isolated in Africa over the 26 years (R<sup>2</sup> = 0.0001, p = 0.92, slope coefficient of -0.05x). Ten types of 23S rRNA mutations (conferring clarithromycin resistance) were identified, and included mainly A2143G (465 H. pylori strains out of 1178 tested) and A2142G (344 H. pylori strains out of 1027).</p><p><strong>Conclusion: </strong>To enhance the accuracy and validity of surveillance data for H. pylori in Africa, there is an urgent need for implementing standardized microbiological methods for resistance detection. The prevalence of CRHp reported in this study was very similar to the overall global prevalence and there is a need for more representative studies on CRHp in Africa. While waiting for this, the treatment of H. pylori infections must be based on the guidelines of the AHMSG first Lagos consensus.</p>\",\"PeriodicalId\":7950,\"journal\":{\"name\":\"Antimicrobial Resistance and Infection Control\",\"volume\":\"14 1\",\"pages\":\"31\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-04-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11993951/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Antimicrobial Resistance and Infection Control\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1186/s13756-025-01533-6\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antimicrobial Resistance and Infection Control","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s13756-025-01533-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0

摘要

背景:2022年,非洲约有56.5%的成年人和47.1%的儿童和青少年感染幽门螺杆菌(H. pylori),耐克拉霉素幽门螺杆菌(CRHp)菌株已成为全球优先考虑的病原体。因此,本研究旨在对非洲CRHp进行首次全面的系统回顾和荟萃分析。方法:本调查按照系统评价和荟萃分析首选报告项目(PRISMA 2020)的指南进行。使用关键词“clarithromycin”、“Helicobacter pylori”、“African country name”、“mutation in 23S rRNA”对电子数据库(谷歌Scholar、African Journals Online、ResearchGate、PubMed、Embase、Scopus)进行文献检索。结果:本研究纳入了来自23个非洲国家26年间(1997-2022)分离的5,313株幽门螺杆菌菌株的65项研究。分离CRHp的样本包括胃活检(60/63;95%),粪便(4/63;6%)。非洲CRHp的总患病率为27% (95% CI: 22,33)。26年来,非洲分离的CRHp患病率呈稳定趋势(R2 = 0.0001, p = 0.92,斜率系数为-0.05x)。鉴定出10种23S rRNA突变(导致克拉霉素耐药),主要包括A2143G(1178株幽门螺杆菌中465株)和A2142G(1027株幽门螺杆菌中344株)。结论:为提高非洲幽门螺旋杆菌监测数据的准确性和有效性,迫切需要实施标准化的微生物学方法进行耐药性检测。本研究报告的CRHp患病率与全球总体患病率非常相似,需要在非洲开展更多具有代表性的CRHp研究。在此期间,幽门螺杆菌感染的治疗必须基于AHMSG第一拉各斯共识的指导方针。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clarithromycin-resistant Helicobacter pylori in Africa: a systematic review and meta-analysis.

Clarithromycin-resistant Helicobacter pylori in Africa: a systematic review and meta-analysis.

Clarithromycin-resistant Helicobacter pylori in Africa: a systematic review and meta-analysis.

Background: In 2022, approximately 56.5% of adults and 47.1% of children and adolescents were affected by Helicobacter pylori (H. pylori) infection in Africa, and clarithromycin-resistant H. pylori (CRHp) strains have become global priority pathogens. Therefore, this study aimed to conduct the first comprehensive systematic review and meta-analysis of CRHp in Africa.

Methods: This investigation was conducted according to the guidelines of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (The PRISMA 2020). Literature search of electronic databases (Google Scholar, African Journals Online, ResearchGate, PubMed, Embase, and Scopus) was performed using keywords "clarithromycin", "Helicobacter pylori", "African country name", "mutation in the 23S rRNA".

Results: Sixty-five studies involving 5,313 H. pylori strains isolated over 26 years (1997-2022) from 23 African countries were included in this study. The samples from which CRHp was isolated included gastric biopsy (60/63; 95%), and stool (4/63; 6%). The pooled prevalence of CRHp in Africa was 27% (95% CI: 22, 33). There was a steady trend in the prevalence of CRHp isolated in Africa over the 26 years (R2 = 0.0001, p = 0.92, slope coefficient of -0.05x). Ten types of 23S rRNA mutations (conferring clarithromycin resistance) were identified, and included mainly A2143G (465 H. pylori strains out of 1178 tested) and A2142G (344 H. pylori strains out of 1027).

Conclusion: To enhance the accuracy and validity of surveillance data for H. pylori in Africa, there is an urgent need for implementing standardized microbiological methods for resistance detection. The prevalence of CRHp reported in this study was very similar to the overall global prevalence and there is a need for more representative studies on CRHp in Africa. While waiting for this, the treatment of H. pylori infections must be based on the guidelines of the AHMSG first Lagos consensus.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Antimicrobial Resistance and Infection Control
Antimicrobial Resistance and Infection Control PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES
CiteScore
9.70
自引率
3.60%
发文量
140
审稿时长
13 weeks
期刊介绍: Antimicrobial Resistance and Infection Control is a global forum for all those working on the prevention, diagnostic and treatment of health-care associated infections and antimicrobial resistance development in all health-care settings. The journal covers a broad spectrum of preeminent practices and best available data to the top interventional and translational research, and innovative developments in the field of infection control.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信