睾酮在男性抑郁症中的作用研究进展。

Q4 Medicine

中国医学科学院学报 Pub Date : 2025-04-30 DOI:10.3881/j.issn.1000-503X.16142

Jia-Min Fu, Qi Guo, Xiao-Yu Chen

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引用次数: 0

摘要

随着社会压力的增加，抑郁症的发病率也在不断上升。睾酮是通过下丘脑-垂体-性腺轴合成和分泌的，对男性的心理健康起着调节作用。研究表明，低睾酮水平、临床性腺功能减退、雄激素剥夺治疗导致的睾酮缺乏与男性抑郁症有显著相关性，但其作用机制仍有许多不确定因素。鉴于睾酮水平低可能是男性抑郁风险的特征性生物标志物，睾酮替代疗法可能对男性抑郁症有良好的治疗效果。本文的重点是评估睾酮水平和相关临床治疗在男性情绪调节中的作用。

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Research Progress in the Role of Testosterone in Male Depression.

As the social pressure is increasing,the incidence of depression is growing.Testosterone is synthesized and secreted through the hypothalamic-pituitary-gonadal axis,which plays a regulatory role in men's mental health.Studies have shown that low testosterone levels,clinical hypogonadism,and androgen deprivation therapy-induced testosterone deficiency are significantly associated with male depression,while there are still many uncertainties about the mechanism of their effects.Given that low testosterone levels may serve as a characteristic biomarker of male depression risk,testosterone replacement therapy may have a good therapeutic effect on male depression.This article focuses on assessing the role of testosterone levels and related clinical therapies in mood regulation in men.

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].