{"title":"胎母出血检测方法综述。","authors":"Xinyang Li, Changfei Li, Tiemei Liu","doi":"10.3389/fphys.2025.1445757","DOIUrl":null,"url":null,"abstract":"<p><p>Fetomaternal haemorrhage is the same immunity that occurs when foetal and maternal blood are incompatible. It is critical to accurately quantify maternal haemorrhaging in order to prevent hemolytic disease in the infant. At this time, the rosette test and K-B test are the most frequently used techniques for detecting foetal red blood cells in the mother's blood. However, the sensitivity of the rosette test is low, and due to its complex operation and high subjectivity, the K-B test cannot be used as a routine clinical detection method. This review therefore focuses primarily on the clinical landscape and future prospects of methods for detecting fetomaternal haemorrhage. In a general sense, this may bring to light the most promising strategy and encourage the development of technology for fetomaternal haemorrhage in order to guarantee the early detection and prevention of hemolytic disease in newborns.</p>","PeriodicalId":12477,"journal":{"name":"Frontiers in Physiology","volume":"16 ","pages":"1445757"},"PeriodicalIF":3.2000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021815/pdf/","citationCount":"0","resultStr":"{\"title\":\"Overview of detection methods of fetomaternal haemorrhage.\",\"authors\":\"Xinyang Li, Changfei Li, Tiemei Liu\",\"doi\":\"10.3389/fphys.2025.1445757\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Fetomaternal haemorrhage is the same immunity that occurs when foetal and maternal blood are incompatible. It is critical to accurately quantify maternal haemorrhaging in order to prevent hemolytic disease in the infant. At this time, the rosette test and K-B test are the most frequently used techniques for detecting foetal red blood cells in the mother's blood. However, the sensitivity of the rosette test is low, and due to its complex operation and high subjectivity, the K-B test cannot be used as a routine clinical detection method. This review therefore focuses primarily on the clinical landscape and future prospects of methods for detecting fetomaternal haemorrhage. In a general sense, this may bring to light the most promising strategy and encourage the development of technology for fetomaternal haemorrhage in order to guarantee the early detection and prevention of hemolytic disease in newborns.</p>\",\"PeriodicalId\":12477,\"journal\":{\"name\":\"Frontiers in Physiology\",\"volume\":\"16 \",\"pages\":\"1445757\"},\"PeriodicalIF\":3.2000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021815/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fphys.2025.1445757\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fphys.2025.1445757","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Overview of detection methods of fetomaternal haemorrhage.
Fetomaternal haemorrhage is the same immunity that occurs when foetal and maternal blood are incompatible. It is critical to accurately quantify maternal haemorrhaging in order to prevent hemolytic disease in the infant. At this time, the rosette test and K-B test are the most frequently used techniques for detecting foetal red blood cells in the mother's blood. However, the sensitivity of the rosette test is low, and due to its complex operation and high subjectivity, the K-B test cannot be used as a routine clinical detection method. This review therefore focuses primarily on the clinical landscape and future prospects of methods for detecting fetomaternal haemorrhage. In a general sense, this may bring to light the most promising strategy and encourage the development of technology for fetomaternal haemorrhage in order to guarantee the early detection and prevention of hemolytic disease in newborns.
期刊介绍:
Frontiers in Physiology is a leading journal in its field, publishing rigorously peer-reviewed research on the physiology of living systems, from the subcellular and molecular domains to the intact organism, and its interaction with the environment. Field Chief Editor George E. Billman at the Ohio State University Columbus is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.