抗tif1 -γ相关皮肌炎伴和非恶性皮肌炎的微血管异常。

IF 2.1 Q3 RHEUMATOLOGY
Sehreen Mumtaz, Jordan Phillipps, Megan M Sullivan, Maximiliano Diaz-Menindez, Benjamin Wang, Vikas Majithia, Emily Craver, Florentina Berianu
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引用次数: 0

摘要

背景:皮肌炎(DM)是一种免疫介导的肌病,以近端肌肉无力、炎症和皮肤表现为特征。高达25%的糖尿病患者伴有相关的恶性肿瘤。与癌症相关的糖尿病患者往往面临较差的预后、较差的治疗反应和较低的生存率。有趣的是,抗tif1 γ阳性的糖尿病患者患恶性肿瘤的风险明显增加,但其潜在机制和临床相关性仍不清楚。甲襞视频毛细血管镜检查(NVC)是一种安全、无创的血管异常评估方法,以前曾在各种糖尿病亚群中进行过研究,但并未专门用于抗tif1 γ阳性的恶性糖尿病患者。本研究旨在描述抗tif1 γ阳性DM中NVC的特征,并评估其临床相关性,特别是在恶性肿瘤相关病例中。方法:回顾性分析2010年1月1日至2024年5月16日在杰克逊维尔梅奥诊所(Mayo Clinic)进行的临床资料。19例抗tif1 γ阳性DM和18例特发性炎性肌病对照。结果:抗tif1 γ阳性DM患者毛细血管密度损失显著增加,微出血发生率显著升高(p = 0.057)。病例也有较高频率的毛细血管扩张、毛细血管分叉和毛细血管紊乱。虽然在癌症与非癌症抗tif1 γ阳性DM中,NVC模式没有统计学上的显著差异,但在癌症抗tif1 γ阳性DM中,有更大的出血和分支。结论:本研究探讨了抗tif1 γ阳性DM伴恶性肿瘤与特发性炎性肌病对照的NVC差异。我们的研究结果表明,微血管差异具有预测癌症发展的潜力,值得在更大规模的研究中进一步探索。临床试验号:不适用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microvascular abnormalities between anti-TIF1-γ-associated dermatomyositis with and without malignancy.

Background: Dermatomyositis (DM) is an immune-mediated myopathy characterized by proximal muscle weakness, inflammation, and cutaneous manifestations. Up to 25% of DM patients have an associated malignancy. Those with cancer-associated DM often face worse prognoses, poorer treatment responses, and reduced survival rates. Interestingly, anti TIF1γ-positive DM patients are notably at increased risk for malignancy, yet the underlying mechanisms and clinical correlation remain poorly understood. Nailfold video capillaroscopy (NVC) is a safe, non-invasive method for assessing vascular abnormalities, previously explored in various DM subsets but not specifically in anti TIF1γ-positive DM patients with malignancy. This study aims to characterize NVC findings in anti-TIF1γ-positive DM and assess their clinical relevance, particularly in malignancy-associated cases.

Methods: A retrospective review at Mayo Clinic, Jacksonville from January 1st, 2010 to May 16th, 2024 was conducted. 19 cases with anti TIF1γ-positive DM and 18 idiopathic inflammatory myopathy controls were included.

Results: We observed anti TIF1γ-positive DM cases to have significantly increased capillary density loss and higher microhemorrhages (p = 0.057). Cases also had higher frequencies of dilated capillaries, capillary ramifications, and capillary disorganization. Although no statistically significant differences in NVC pattern were identified in cancer vs. non-cancer anti TIF1γ-positive DM, there were greater hemorrhages and ramifications noted in the cancer anti TIF1γ-positive subset.

Conclusion: This study investigated NVC differences among anti TIF1γ-positive DM with malignancies versus idiopathic inflammatory myopathy controls. Our findings indicate promising microvascular differences with a potential for predicting cancer development that warrant further exploration in larger studies.

Clinical trial number: Not applicable.

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来源期刊
BMC Rheumatology
BMC Rheumatology Medicine-Rheumatology
CiteScore
3.80
自引率
0.00%
发文量
73
审稿时长
15 weeks
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