Marlon D Joseph, Dmitrii Krivorotko, Martha R Koenig, Amelia K Wesselink, Michael L Eisenberg, Greg J Sommer, Kenneth J Rothman, Sherri O Stuver, Elizabeth E Hatch, Lauren A Wise
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After enrollment, we invited participants to perform at-home semen testing. We used linear regression to estimate percent differences in mean semen parameter values (%D) and 95% confidence intervals (CI) for associations between cannabis use and semen volume (mL), total sperm count (TSC, million), sperm concentration (million/mL), motility (%), and total motile sperm count (TMSC, million), controlling for potential confounders. We used log-binomial regression to estimate risk ratios (RRs) for low semen quality based on 2021 World Health Organization cut-points.</p><p><strong>Results: </strong>Overall, 22.6% of participants reported current cannabis use and 3.3% reported daily use. Nearly 6% of participants had low semen volume (≤1.5 mL), 13% low sperm concentration (≤15 million/L), 8% low TSC (≤39 million), 25% low sperm motility (≤40%), and 11% low TMSC (≤16 million). Adjusted %Ds (95% CIs) comparing current cannabis use versus non-use were -3.2 (-9.1, 2.7) for semen volume, 3.5 (-10.3, 19.5) for sperm concentration, -0.6 (-14.3, 15.3) for TSC, 2.5 (-2.9, 8.0) for motility, and 3.0 (-13.4, 22.4) for TMSC. Cannabis use ≥1 times/week (vs. non-use) was associated with low semen volume (RR = 2.16, 95% CI = 0.93-5.04). Associations were imprecise and showed no monotonic association between frequency of cannabis use and the semen parameters evaluated.</p><p><strong>Conclusion: </strong>In this North American preconception cohort study, current cannabis use was not appreciably associated with semen quality.</p>","PeriodicalId":7898,"journal":{"name":"Andrology","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A North American preconception cohort study of cannabis use and semen quality.\",\"authors\":\"Marlon D Joseph, Dmitrii Krivorotko, Martha R Koenig, Amelia K Wesselink, Michael L Eisenberg, Greg J Sommer, Kenneth J Rothman, Sherri O Stuver, Elizabeth E Hatch, Lauren A Wise\",\"doi\":\"10.1111/andr.70056\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Recreational and medicinal use of cannabis is increasing among North American reproductive-aged couples. Studies of cannabis use and semen quality are limited and have produced inconsistent findings.</p><p><strong>Objectives: </strong>We examined the association between male cannabis use and semen parameters.</p><p><strong>Materials and methods: </strong>We analyzed data from 1654 semen samples contributed by 921 male participants in Pregnancy Study Online (PRESTO), a North American preconception cohort study. Participants aged ≥21 years completed a baseline questionnaire on which they reported their cannabis use within the past 2 months. After enrollment, we invited participants to perform at-home semen testing. We used linear regression to estimate percent differences in mean semen parameter values (%D) and 95% confidence intervals (CI) for associations between cannabis use and semen volume (mL), total sperm count (TSC, million), sperm concentration (million/mL), motility (%), and total motile sperm count (TMSC, million), controlling for potential confounders. 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引用次数: 0
摘要
背景：北美育龄夫妇对大麻的娱乐性和药用性使用正在增加。关于大麻使用和精液质量的研究是有限的，并且得出了不一致的结果。目的：我们研究了男性大麻使用与精液参数之间的关系。材料和方法：我们分析了北美孕前队列研究妊娠研究在线（PRESTO）中921名男性参与者提供的1654份精液样本的数据。年龄≥21岁的参与者完成了一份基线问卷，报告了他们在过去2个月内的大麻使用情况。登记后，我们邀请参与者在家中进行精液检测。我们使用线性回归来估计大麻使用与精液体积（mL）、总精子数（TSC，百万）、精子浓度（百万/mL）、活动性（%）和总活动精子数（TMSC，百万）之间相关性的平均精液参数值（%D）和95%置信区间（CI）的百分比差异，并控制潜在的混杂因素。我们使用对数二项回归来估计基于2021年世界卫生组织切割点的低精液质量的风险比（rr）。结果：总体而言，22.6%的参与者报告目前使用大麻，3.3%报告每天使用大麻。近6%的参与者精液量低（≤1.5 mL）， 13%的参与者精子浓度低（≤1500万/L）， 8%的参与者TSC低（≤3900万），25%的参与者精子活力低（≤40%），11%的参与者TMSC低（≤1600万）。目前使用大麻与不使用大麻的校正% d （95% ci）比较，精液量为-3.2(-9.1,2.7)，精子浓度为3.5 (-10.3,19.5)，TSC为-0.6(-14.3,15.3)，活力为2.5 (-2.9,8.0)，TMSC为3.0（-13.4,22.4）。大麻使用≥1次/周（与不使用相比）与精液量低相关（RR = 2.16, 95% CI = 0.93-5.04）。关联是不精确的，并没有显示大麻使用频率和精液参数评估之间的单调关联。结论：在这项北美孕前队列研究中，目前大麻的使用与精液质量没有明显的关系。
A North American preconception cohort study of cannabis use and semen quality.
Background: Recreational and medicinal use of cannabis is increasing among North American reproductive-aged couples. Studies of cannabis use and semen quality are limited and have produced inconsistent findings.
Objectives: We examined the association between male cannabis use and semen parameters.
Materials and methods: We analyzed data from 1654 semen samples contributed by 921 male participants in Pregnancy Study Online (PRESTO), a North American preconception cohort study. Participants aged ≥21 years completed a baseline questionnaire on which they reported their cannabis use within the past 2 months. After enrollment, we invited participants to perform at-home semen testing. We used linear regression to estimate percent differences in mean semen parameter values (%D) and 95% confidence intervals (CI) for associations between cannabis use and semen volume (mL), total sperm count (TSC, million), sperm concentration (million/mL), motility (%), and total motile sperm count (TMSC, million), controlling for potential confounders. We used log-binomial regression to estimate risk ratios (RRs) for low semen quality based on 2021 World Health Organization cut-points.
Results: Overall, 22.6% of participants reported current cannabis use and 3.3% reported daily use. Nearly 6% of participants had low semen volume (≤1.5 mL), 13% low sperm concentration (≤15 million/L), 8% low TSC (≤39 million), 25% low sperm motility (≤40%), and 11% low TMSC (≤16 million). Adjusted %Ds (95% CIs) comparing current cannabis use versus non-use were -3.2 (-9.1, 2.7) for semen volume, 3.5 (-10.3, 19.5) for sperm concentration, -0.6 (-14.3, 15.3) for TSC, 2.5 (-2.9, 8.0) for motility, and 3.0 (-13.4, 22.4) for TMSC. Cannabis use ≥1 times/week (vs. non-use) was associated with low semen volume (RR = 2.16, 95% CI = 0.93-5.04). Associations were imprecise and showed no monotonic association between frequency of cannabis use and the semen parameters evaluated.
Conclusion: In this North American preconception cohort study, current cannabis use was not appreciably associated with semen quality.
期刊介绍：
Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology
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