内源性和外源性催产素调节自闭症的人际运动共振:一种情境依赖和个体特异性的方法。

IF 5.6 2区 心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL
Autism Pub Date : 2025-08-01 Epub Date: 2025-05-11 DOI:10.1177/13623613251335730
Jellina Prinsen, Kaat Alaerts
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引用次数: 0

摘要

理解和解释非语言行为是社会认知的重要组成部分,这对自闭症患者来说往往是一个挑战。催产素是一种神经肽,可以调节社会行为,增强社会刺激的显著性,目前正在探索作为改善社会镜像的治疗选择。然而,其影响是由环境和个人依赖因素介导的。本研究考察了单次鼻内剂量催产素(24 IU)对有或无自闭症的年轻成年男性人际运动共振的影响。使用经颅磁刺激对皮质运动兴奋性进行神经生理学评估,同时参与者观察实验者显示的实时手部运动,显示不同的社交意图(即显示直视和转移凝视)。虽然没有观察到催产素对人际运动共振的总体影响,但个体特异性因素显著影响结果。在自闭症组中,内源性催产素水平较高的个体在动作观察中表现出更大的运动共振。具有高度社交困难或回避型依恋类型的自闭症个体在催产素治疗后表现出增强的运动共振。这些发现强调了内源性和外源性催产素在形成神经生理运动共振中的微妙作用,并强调了评估催产素在解决自闭症社会挑战方面的治疗潜力的个体差异的重要性。这项研究探讨了催产素,一种影响社会行为的激素,是如何影响对非语言线索的解释和反应能力的,特别是在自闭症成年人中。理解他人的行为和意图,通常通过观察肢体语言和眼神交流来指导,是社交互动的关键部分。自闭症患者经常在这些方面面临挑战。这项研究使用一种安全的、非侵入性的大脑刺激技术,测量了参与者在观察与互动伙伴的直接目光接触或回避目光配对的实时手部运动时的大脑反应。参与者包括年轻的自闭症和非自闭症的成年男性,他们通过鼻腔喷雾剂接受安慰剂和单剂量的催产素。结果显示,两组人的大脑对这些运动的反应没有总体差异。然而,在自闭症组中,有几个因素显著影响催产素的效果。天然催产素水平较高的参与者或那些面临更大社会挑战的参与者在服用催产素后表现出更强的反应,特别是在观察手部运动并直视时。这些发现表明,催产素可能会提高自闭症患者的社会理解能力,尤其是对那些遇到更大困难的人。当考虑将催产素作为改善社会互动的治疗选择时,这突出了个性化方法的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endogenous and exogenous oxytocin modulate interpersonal motor resonance in autism: A context-dependent and person-specific approach.

Understanding and interpreting non-verbal actions are critical components of social cognition, which are often challenging for autistic individuals. Oxytocin, a neuropeptide known to modulate social behavior and enhance the salience of social stimuli, is being explored as a therapeutic option for improving social mirroring. However, its effects are mediated by context- and person-dependent factors. This study examines the impact of a single intranasal dose of oxytocin (24 IU) on interpersonal motor resonance in young adult men with and without autism. Neurophysiological assessments of corticomotor excitability were performed using transcranial magnetic stimulation while participants observed real-time hand movements displayed by an experimenter demonstrating varying social intent (i.e. showing direct vs averted gaze). While no overall effect of oxytocin on interpersonal motor resonance was observed across groups, person-specific factors significantly influenced outcomes. In the autism group, individuals with higher endogenous oxytocin levels exhibited greater motor resonance during action observation. Autistic individuals with heightened social difficulties or avoidant attachment styles showed enhanced motor resonance following oxytocin administration. These findings highlight the nuanced role of both endogenous and exogenous oxytocin in shaping neurophysiological motor resonance and emphasize the importance of individual variability in assessing oxytocin's therapeutic potential for addressing social challenges in autism.Lay abstractThis study explores how oxytocin, a hormone that influences social behaviors, affects the ability to interpret and respond to non-verbal cues, particularly in autistic adults. Understanding others' actions and intentions, often guided by observing body language and eye contact, is a critical part of social interaction. Autistic individuals frequently face challenges in these areas. Using a safe, non-invasive brain stimulation technique, the study measured participants' brain responses as they observed real-time hand movements paired with the interaction partner's direct eye contact or averted gaze. Participants included young autistic and non-autistic adult men who received a placebo and a single dose of oxytocin via nasal spray. Results showed no overall differences between the two groups in their brain responses to these movements. However, in the autism group, several factors significantly influenced the effects of oxytocin. Participants with higher natural oxytocin levels or those who reported greater social challenges showed stronger responses after oxytocin administration, particularly when observing hand movements combined with direct gaze. These findings suggest that oxytocin may enhance social understanding in autistic individuals, especially for those experiencing greater difficulties. This highlights the potential of personalized approaches when considering oxytocin as a therapeutic option to improve social interactions.

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来源期刊
Autism
Autism PSYCHOLOGY, DEVELOPMENTAL-
CiteScore
9.80
自引率
11.50%
发文量
160
期刊介绍: Autism is a major, peer-reviewed, international journal, published 8 times a year, publishing research of direct and practical relevance to help improve the quality of life for individuals with autism or autism-related disorders. It is interdisciplinary in nature, focusing on research in many areas, including: intervention; diagnosis; training; education; translational issues related to neuroscience, medical and genetic issues of practical import; psychological processes; evaluation of particular therapies; quality of life; family needs; and epidemiological research. Autism provides a major international forum for peer-reviewed research of direct and practical relevance to improving the quality of life for individuals with autism or autism-related disorders. The journal''s success and popularity reflect the recent worldwide growth in the research and understanding of autistic spectrum disorders, and the consequent impact on the provision of treatment and care. Autism is interdisciplinary in nature, focusing on evaluative research in all areas, including: intervention, diagnosis, training, education, neuroscience, psychological processes, evaluation of particular therapies, quality of life issues, family issues and family services, medical and genetic issues, epidemiological research.
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