Gagana Weerasinghe, Bram Servais, Daniel Heath, Samuel T Martin, David J Collins
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Improved acoustic holograms using simulated annealing.
Acoustic holography offers the ability to generate designed acoustic fields, enhancing the versatility of acoustic micromanipulation. However, the quality of the generated holograms depends on the nature of the iterative algorithm that is utilized, where the iterative angular spectrum approach (IASA) has been the standard method to date. Here, we introduce a novel approach that categorically improves IASA performance, where we apply the principles of simulated annealing for the generation of high-quality acoustic holograms. We utilize this to realize significant improvements in hologram quality via simulations, fabricated holograms, experimental particle patterning, and high-resolution 2D hydrophone scans. Comparing holograms produced from IASA and/or simulated annealing, we demonstrate that the use of simulated annealing in acoustic holography results in sharper reconstructions and improved hologram outputs across a range of evaluation metrics.
期刊介绍:
Biomicrofluidics (BMF) is an online-only journal published by AIP Publishing to rapidly disseminate research in fundamental physicochemical mechanisms associated with microfluidic and nanofluidic phenomena. BMF also publishes research in unique microfluidic and nanofluidic techniques for diagnostic, medical, biological, pharmaceutical, environmental, and chemical applications.
BMF offers quick publication, multimedia capability, and worldwide circulation among academic, national, and industrial laboratories. With a primary focus on high-quality original research articles, BMF also organizes special sections that help explain and define specific challenges unique to the interdisciplinary field of biomicrofluidics.
Microfluidic and nanofluidic actuation (electrokinetics, acoustofluidics, optofluidics, capillary)
Liquid Biopsy (microRNA profiling, circulating tumor cell isolation, exosome isolation, circulating tumor DNA quantification)
Cell sorting, manipulation, and transfection (di/electrophoresis, magnetic beads, optical traps, electroporation)
Molecular Separation and Concentration (isotachophoresis, concentration polarization, di/electrophoresis, magnetic beads, nanoparticles)
Cell culture and analysis(single cell assays, stimuli response, stem cell transfection)
Genomic and proteomic analysis (rapid gene sequencing, DNA/protein/carbohydrate arrays)
Biosensors (immuno-assay, nucleic acid fluorescent assay, colorimetric assay, enzyme amplification, plasmonic and Raman nano-reporter, molecular beacon, FRET, aptamer, nanopore, optical fibers)
Biophysical transport and characterization (DNA, single protein, ion channel and membrane dynamics, cell motility and communication mechanisms, electrophysiology, patch clamping). Etc...