Siqi Li, Jun Liu, Guanyun Wang, Ying Kan, Wei Wang, Jigang Yang
{"title":"18F-FDG PET/CT体积参数预测MYCN增益神经母细胞瘤的预后。","authors":"Siqi Li, Jun Liu, Guanyun Wang, Ying Kan, Wei Wang, Jigang Yang","doi":"10.1007/s00261-025-04973-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to evaluate the value of <sup>18</sup>F-FDG PET/CT metabolic parameters in neuroblastoma (NB) with MYCN gain.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 87 patients with NB (29 with MYCN gain and 58 with MYCN normal). The region of interest of primary tumors were manually delineated using 3D slicer™ software, and <sup>18</sup>F-FDG PET/CT metabolic parameters, including SUV<sub>max</sub>, SUV<sub>peak</sub>, SUV<sub>mean</sub>, MTV and TLG were extracted. Logistic regression analyses were used to identify the relationship between <sup>18</sup>F-FDG PET/CT metabolic parameters and MYCN gain. Cox proportional hazards regression models were used to assess the associations between <sup>18</sup>F-FDG PET/CT metabolic parameters and EFS and OS. Survival curves were generated using the Kaplan-Meier method, and differences in survival between groups were compared using the log-rank test.</p><p><strong>Results: </strong>A total of 87 NB patients [median age: 40 (20-56) months; 48 girls and 39 boys] were evaluated. Logistic regression analyses revealed that MTV (>133.3 cm<sup>3</sup>) was an independent predictor of MYCN gain. During the follow-up period of 22 (2-70) months, 21 patients died and 37 patients experienced disease recurrence or progression. Cox proportional hazards regression analyses showed that MTV, in combination with PHOX2B, was an independent prognostic factor for EFS and OS in NB patients with MYCN-gain. Patients with high MTV exhibited significantly shorter EFS and OS compared to those with low MTV.</p><p><strong>Conclusion: </strong>The volumetric parameter MTV derived from <sup>18</sup>F-FDG PET/CT imaging can predict MYCN gain in NB patients and provide valuable prognostic information for patients with MYCN-gain NB.</p>","PeriodicalId":7126,"journal":{"name":"Abdominal Radiology","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"<sup>18</sup>F-FDG PET/CT volumetric parameter predicts prognosis for neuroblastoma with MYCN gain.\",\"authors\":\"Siqi Li, Jun Liu, Guanyun Wang, Ying Kan, Wei Wang, Jigang Yang\",\"doi\":\"10.1007/s00261-025-04973-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The aim of the study was to evaluate the value of <sup>18</sup>F-FDG PET/CT metabolic parameters in neuroblastoma (NB) with MYCN gain.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 87 patients with NB (29 with MYCN gain and 58 with MYCN normal). The region of interest of primary tumors were manually delineated using 3D slicer™ software, and <sup>18</sup>F-FDG PET/CT metabolic parameters, including SUV<sub>max</sub>, SUV<sub>peak</sub>, SUV<sub>mean</sub>, MTV and TLG were extracted. Logistic regression analyses were used to identify the relationship between <sup>18</sup>F-FDG PET/CT metabolic parameters and MYCN gain. Cox proportional hazards regression models were used to assess the associations between <sup>18</sup>F-FDG PET/CT metabolic parameters and EFS and OS. Survival curves were generated using the Kaplan-Meier method, and differences in survival between groups were compared using the log-rank test.</p><p><strong>Results: </strong>A total of 87 NB patients [median age: 40 (20-56) months; 48 girls and 39 boys] were evaluated. Logistic regression analyses revealed that MTV (>133.3 cm<sup>3</sup>) was an independent predictor of MYCN gain. During the follow-up period of 22 (2-70) months, 21 patients died and 37 patients experienced disease recurrence or progression. Cox proportional hazards regression analyses showed that MTV, in combination with PHOX2B, was an independent prognostic factor for EFS and OS in NB patients with MYCN-gain. Patients with high MTV exhibited significantly shorter EFS and OS compared to those with low MTV.</p><p><strong>Conclusion: </strong>The volumetric parameter MTV derived from <sup>18</sup>F-FDG PET/CT imaging can predict MYCN gain in NB patients and provide valuable prognostic information for patients with MYCN-gain NB.</p>\",\"PeriodicalId\":7126,\"journal\":{\"name\":\"Abdominal Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Abdominal Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00261-025-04973-1\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Abdominal Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00261-025-04973-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
18F-FDG PET/CT volumetric parameter predicts prognosis for neuroblastoma with MYCN gain.
Purpose: The aim of the study was to evaluate the value of 18F-FDG PET/CT metabolic parameters in neuroblastoma (NB) with MYCN gain.
Methods: A retrospective analysis was conducted on 87 patients with NB (29 with MYCN gain and 58 with MYCN normal). The region of interest of primary tumors were manually delineated using 3D slicer™ software, and 18F-FDG PET/CT metabolic parameters, including SUVmax, SUVpeak, SUVmean, MTV and TLG were extracted. Logistic regression analyses were used to identify the relationship between 18F-FDG PET/CT metabolic parameters and MYCN gain. Cox proportional hazards regression models were used to assess the associations between 18F-FDG PET/CT metabolic parameters and EFS and OS. Survival curves were generated using the Kaplan-Meier method, and differences in survival between groups were compared using the log-rank test.
Results: A total of 87 NB patients [median age: 40 (20-56) months; 48 girls and 39 boys] were evaluated. Logistic regression analyses revealed that MTV (>133.3 cm3) was an independent predictor of MYCN gain. During the follow-up period of 22 (2-70) months, 21 patients died and 37 patients experienced disease recurrence or progression. Cox proportional hazards regression analyses showed that MTV, in combination with PHOX2B, was an independent prognostic factor for EFS and OS in NB patients with MYCN-gain. Patients with high MTV exhibited significantly shorter EFS and OS compared to those with low MTV.
Conclusion: The volumetric parameter MTV derived from 18F-FDG PET/CT imaging can predict MYCN gain in NB patients and provide valuable prognostic information for patients with MYCN-gain NB.
期刊介绍：
Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section.
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