双侧突发性听力损失患者自身免疫和炎症标志物的评价

IF 2.2 3区 医学 Q2 OTORHINOLARYNGOLOGY
Aynur Aliyeva, Elif Sari
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引用次数: 0

摘要

背景:双侧突发性听力损失(BSHL)是一种罕见的耳科急症,占所有突发性听力损失病例的1-2%。自身免疫过程被认为是BSHL的关键因素之一,免疫反应针对内耳结构。本研究的目的是确定自身免疫和炎症标志物在BSHL患者中的作用,并评估其预后意义。材料与方法:回顾性研究420例突发性听力损失病例中的30例BSHL患者。数据包括听力学结果、病史、自身免疫和炎症标志物(ANA、RF、ESR、CRP、ACA、ANCA)以及自身免疫性疾病,如强直性脊柱炎(as)、甲状腺功能减退(HT)、类风湿性关节炎(RA)和系统性红斑狼疮(SLE)。使用Siegel标准评估听力恢复,并评估自身免疫标记物的存在对临床结果和恢复的影响。结果:60%的BSHL患者检测到自身免疫标志物,其中以ANA、RF、ESR和CRP水平升高最为常见。自身免疫标志物检测呈阳性的患者与标志物未呈阳性的患者相比,恢复率明显较低。具体来说,13%的阳性标记患者听力部分恢复,而100%的无标记患者听力部分恢复。所有频率的平均听力改善约为21.5 dB。这些结果表明,自身免疫标记物阳性与标准皮质类固醇治疗后较差的临床结果和较低的治愈率相关。结论:我们的研究表明,自身免疫和炎症标志物在BSHL的预后中起重要作用。自身免疫标记阳性的患者表现出较差的恢复率,表明这些标记在预测BSHL治疗结果方面的潜在重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of autoimmune and inflammatory markers in bilateral sudden hearing loss.

Evaluation of autoimmune and inflammatory markers in bilateral sudden hearing loss.

Evaluation of autoimmune and inflammatory markers in bilateral sudden hearing loss.

Background: Bilateral sudden hearing loss (BSHL) is a rare otologic emergency, representing 1-2% of all sudden hearing loss cases. Autoimmune processes are considered one of the key contributors to BSHL, with immune responses targeting inner ear structures. The aim of our study is to identify the role of autoimmune and inflammatory markers in patients with BSHL and assess their prognostic significance.

Materials and methods: This retrospective study reviewed 30 BSHL patients out of 420 sudden hearing loss cases. Data including audiometric results, medical histories, autoimmune and inflammatory markers (ANA, RF, ESR, CRP, ACA, ANCA), and autoimmune diseases such as Ankylosing Spondylitis (AS), Hypothyroidism (HT), Rheumatoid Arthritis (RA), and Systemic Lupus Erythematosus (SLE) were analyzed. Audiometric recovery was assessed using Siegel's criteria, and the presence of autoimmune markers was evaluated for their impact on clinical outcomes and recovery.

Results: Autoimmune markers were detected in 60% of the patients with BSHL, with elevated levels of ANA, RF, ESR, and CRP observed most frequently. Patients who tested positive for autoimmune markers demonstrated significantly lower recovery rates compared to those without marker positivity. Specifically, 13% of patients with positive markers showed partial hearing recovery, while 100% of patients without markers exhibited partial recovery. The average hearing improvement across all frequencies was around 21.5 dB. These results suggest that autoimmune marker positivity is associated with poorer clinical outcomes and lower recovery rates following standard corticosteroid treatment.

Conclusion: Our study demonstrates that autoimmune and inflammatory markers play a significant role in the prognosis of BSHL. Patients with positive autoimmune markers exhibit poorer recovery rates, indicating the potential importance of these markers in predicting treatment outcomes for BSHL.

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来源期刊
CiteScore
5.30
自引率
7.70%
发文量
537
审稿时长
2-4 weeks
期刊介绍: Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.
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