环状rna在调节肿瘤细胞因子信号传导中的作用。

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

FEBS Open Bio Pub Date : 2025-05-12 DOI:10.1002/2211-5463.70051

Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma

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引用次数: 0

摘要

细胞因子信号的失调是癌症发生和发展的核心。细胞因子不仅参与促进肿瘤的发展，还参与调节抗肿瘤免疫反应。环状RNA （circRNAs）是单链、共价封闭的RNA分子，缺乏自由端，已成为细胞因子信号传导的关键调节因子。circRNAs对细胞因子信号的转录和转录后调控有助于癌症的发病。在这里，我们讨论了环状rna在调节癌症发展的细胞因子信号通路中的新作用。特别是，我们研究了circrna在TGF-β、IL-6、IL-10、TNF-α、VEGF、FGF、PDGF和趋化因子信号传导中的作用。

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The role of circular RNAs in regulating cytokine signaling in cancer.

Dysregulation of cytokine signaling is central to the development and progression of cancer. Cytokines are not only involved in promoting cancer development but also regulate anti-tumor immune responses. Circular RNAs (circRNAs) are single-stranded, covalently closed RNA molecules lacking free ends, which have emerged as critical regulators of cytokine signaling. Transcriptional and post-transcriptional regulation of cytokine signaling by circRNAs contributes to cancer pathogenesis. Here, we discuss the emerging role of circRNAs in modulating cytokine signaling pathways that regulate cancer development. In particular, we examine the role of circRNAs in TGF-β, IL-6, IL-10, TNF-α, VEGF, FGF, PDGF, and chemokine signaling in cancer.

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来源期刊

FEBS Open Bio BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

173

审稿时长

10 weeks

期刊介绍： FEBS Open Bio is an online-only open access journal for the rapid publication of research articles in molecular and cellular life sciences in both health and disease. The journal''s peer review process focuses on the technical soundness of papers, leaving the assessment of their impact and importance to the scientific community. FEBS Open Bio is owned by the Federation of European Biochemical Societies (FEBS), a not-for-profit organization, and is published on behalf of FEBS by FEBS Press and Wiley. Any income from the journal will be used to support scientists through fellowships, courses, travel grants, prizes and other FEBS initiatives.