皮肤软组织扩张和重组人表皮生长因子在二度烫伤瘢痕修复中的疗效:一项前瞻性单盲随机对照试验。

IF 1.2 4区 医学 Q3 SURGERY
Hui He, Miaomiao Xu, Wenlu Zhang, Jia Ye
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引用次数: 0

摘要

目的:观察软组织扩张联合重组人表皮生长因子(rhEGF)修复二度烫伤疤痕的疗效和安全性。方法:采用前瞻性、单盲、随机对照试验。84例深二度烫伤瘢痕患者平均分为对照组和观察组。对照组给予软组织扩张治疗,观察组在对照组基础上给予rhEGF治疗。比较皮肤扩张和伤口愈合时间。观察一期手术后创面渗出及周围炎症的变化。在手术第二阶段比较羟基脯氨酸(OHP)和胶原I/III比率。观察治疗过程中的并发症及修复效果。结果:观察组患者扩张时间、即刻缩回率、创面愈合时间均低于对照组,皮肤扩张率、创面渗出评分、炎症评分、OHP、I/III胶原、并发症发生率均低于对照组,总有效率高于对照组(P < 0.05)。结论:皮肤软组织扩张联合rhEGF修复二度烫伤瘢痕更为有效,可有效增加皮肤扩张面积,减少创面感染及并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The efficacy of skin soft tissue expansion and recombinant human epidermal growth factor in the repair of second-degree scald scars: a prospective single-blind randomized controlled trial.

Purpose: This research observed the efficacy and safety of soft tissue expansion combined with recombinant human epidermal growth factor (rhEGF) in repairing second-degree scald scars.

Methods: This study conducted a prospective, single-blind, randomized controlled trial. Eighty-four patients with deep second-degree scald scars were evenly divided into the control and observation groups. The control group was treated with soft tissue expansion, and the observation group was additionally treated with rhEGF. The skin expansion and wound healing times were compared. The changes in wound exudate and inflammation around the wound were observed after first-stage surgery. The hydroxyproline (OHP) and collagen I/III ratios were compared during the second stage of surgery. The complications and repair effects during treatment were evaluated.

Results: The observation group exhibited lower expansion time, immediate retraction rate, and wound healing time, higher skin expansion rate, higher wound exudate score and inflammation score, higher OHP, lower collagen I/III, lower complication rate, and higher total effective rate than the control group (all P < 0.05).

Conclusion: Skin soft tissue expansion combined with rhEGF is more effective in repairing second-degree scald scars, which can effectively increase skin expansion area and reduce wound infection and complications.

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来源期刊
CiteScore
2.30
自引率
7.10%
发文量
75
期刊介绍: Manuscripts to the Annals of Surgical Treatment and Research (Ann Surg Treat Res) should be written in English according to the instructions for authors. If the details are not described below, the style should follow the Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publications available at International Committee of Medical Journal Editors (ICMJE) website (http://www.icmje.org).
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