仙人掌三萜皂苷抑制淀粉样蛋白-β聚集活性的研究。

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL

Journal of Natural Medicines Pub Date : 2025-05-08 DOI:10.1007/s11418-025-01905-7

Tatsumi Matsumoto, Koji Fujihara, Tomomi Inayama, Hiroaki Sasaki, Kaoru Kinoshita

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引用次数: 0

摘要

从胶状小木耳（Stenocereus gummosus, Engelm.）的MeOH提取物中分离到7个新的三萜皂苷（1-7）和2个已知的皂苷（8,9）。a.c.吉布森和K.E.Horak。通过质谱、红外光谱和核磁共振综合测定对分离得到的皂苷进行了结构鉴定。为了根据淀粉样蛋白级联假说开发治疗阿尔茨海默病（AD）的药物，采用硫黄素- t （Th-T）试验评估了分离的皂苷对淀粉样蛋白β (Aβ)聚集的抑制作用。其中化合物1、2、8和9活性较弱（IC50分别为39.0、36.7、39.5和35.7µM）。皂苷苷元gummosogenin和alamosenogenin的IC50分别为14.9µM和15.5µM，具有抑制Aβ聚集的活性。

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Amyloid-β aggregation inhibitory activity of triterpene saponins from the cactus Stenocereus gummosus.

Seven new triterpene saponins (1-7) and two known saponins (8, 9) were isolated from MeOH extracts of Stenocereus gummosus (Engelm.) A.C.Gibson & K.E.Horak. The structures of the isolated saponins were elucidated using MS, IR and comprehensive NMR measurements. To develop drugs for treating Alzheimer's disease (AD) based on the amyloid cascade hypothesis, the isolated saponins were evaluated for inhibition of amyloid beta (Aβ) aggregation using the thioflavin-T (Th-T) assay. Among the isolated saponins, weak activity was observed for compounds 1, 2, 8 and 9 (IC₅₀ = 39.0, 36.7, 39.5, and 35.7 µM, respectively). The aglycons of the isolated saponins, gummosogenin and alamosenogenin, also showed inhibitory activity related to Aβ aggregation (IC₅₀ = 14.9 and 15.5 µM, respectively).

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.