多次光动力治疗慢性中枢性浆液性脉络膜视网膜病变的疗效和安全性。

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Jennifer M Chang-Wolf, Elon H C van Dijk, Kamal El Boujdaini, Mitchel van Straaten, Thomas J van Rijssen, Reinier O Schlingemann, Camiel J F Boon, Roselie M H Diederen
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引用次数: 0

摘要

目的:本研究评估多次PDT治疗慢性中枢性浆液性脉络膜视网膜病变(CSC)持续性和复发性视网膜下积液(SRF)的有效性和安全性。方法:这项多中心、回顾性队列研究纳入了2009年8月至2025年2月期间在阿姆斯特丹大学医学中心或莱顿大学医学中心接受至少两次PDT治疗的年龄≥18岁的慢性CSC患者。结果包括SRF的分辨率,视力(VA)的变化,中央凹下脉络膜厚度(SFCT)和外限制膜(ELM)和椭球带(EZ)的连续性。结果:本研究纳入88例慢性CSC患者,其中88.6%为男性。在105只接受治疗的眼睛中,62.5%的人在第一次PDT后有持续的SRF,而37.5%的人达到了完全的SRF分辨率。第二次PDT后,62.8%的眼睛SRF完全消失,其中持续性SRF组为53.1%,复发性SRF组为64.1%。第三次PDT后,67.7%的患者SRF完全缓解。第二次PDT后VA比基线改善了3±2个字母(p = 0.033),复发性SRF组改善更大。两组患者经PDT治疗后SFCT均低于基线。ELM和EZ连续性在光学相干断层扫描上也普遍显示出改善,特别是在复发性SRF组,这表明视网膜完整性恢复而不是萎缩变化。结论:重复PDT治疗对于持续性和复发性慢性CSC都是一种有效且安全的治疗方法,可改善SRF、VA、SFCT和视网膜层连续性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outcome and safety of multiple photodynamic therapy sessions in chronic central serous chorioretinopathy.

Purpose: This study evaluates the effectiveness and safety of multiple PDT sessions for cases of persistent and recurrent subretinal fluid (SRF) in chronic central serous chorioretinopathy (CSC).

Methods: This multicentre, retrospective cohort study included patients aged ≥18 years with chronic CSC who received at least two sessions of PDT at Amsterdam University Medical Center or Leiden University Medical Center between August 2009 and February 2025. Outcomes included the resolution of SRF, changes in visual acuity (VA), subfoveal choroidal thickness (SFCT) and continuity of the external limiting membrane (ELM) and ellipsoid zone (EZ).

Results: The study included 88 patients with chronic CSC, of whom 88.6% were male. Of the 105 eyes treated, 62.5% had persistent SRF after the first PDT, while 37.5% achieved complete SRF resolution. After the second PDT, SRF resolved completely in 62.8% of eyes overall, with 53.1% in the persistent SRF group and 64.1% in the recurrent SRF group. Following the third PDT, 67.7% of patients showed complete SRF resolution. VA improved by 3 ± 2 letters (p = 0.033) above baseline after the second PDT, with the recurrent SRF group showing greater improvements. SFCT was lower than baseline after PDT treatments in both groups. ELM and EZ continuity also generally showed improvements on optical coherence tomography, particularly in the recurrent SRF group, suggesting retinal integrity restoration rather than atrophic changes.

Conclusion: Repeated PDT is an effective and safe treatment for both persistent and recurrent chronic CSC, with improvements in SRF, VA, SFCT and retinal layer continuity.

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来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
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