氢解裂解螺环丙烷合成2-乙酰氨基诺维胺衍生物。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-04-16 DOI:10.1039/d5ob00469a

Maruan D. Salim , Isabella Ferrara , Olivier Blacque , Karl Gademann

引用次数: 0

摘要

本文报道了一种罕见的5,5-gem-二甲基脱氧碳水化合物的2-乙酰氨基衍生物的制备。合成从现成的n -乙酰-d -甘露糖胺开始，通过环丙化和氢解裂解策略引入宝石二甲基结构特征，这可以合成L-和d -甘露糖的2-氨基衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 2-acetylnoviosamine derivatives by hydrogenolytic cleavage of a spirocyclopropane†

The preparation of a 2-acetamido derivative of the rare 5,5-gem-dimethyl-deoxy carbohydrate noviose is reported in this study. The synthesis starts from readily available N-acetyl-d-mannosamine and tackles the introduction of the gem-dimethyl structural feature via a cyclopropanation and hydrogenolytic cleavage strategy, which can enable the synthesis of 2-amino noviose derivatives of both l- and d-noviose.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.