免疫调节酶。

IF 2 4区生物学 Q4 CELL BIOLOGY

Acta Naturae Pub Date : 2025-01-01 DOI:10.32607/actanaturae.27549

S V Kupriyanov, K M Kirilenko, D N Starkov

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引用次数: 0

摘要

免疫调节酶作为生物催化剂和调节元件，在控制免疫应答中起着至关重要的作用。这些蛋白的功能障碍可导致各种病理状况，如抗肿瘤免疫抑制或抗感染免疫反应受损。本文综述了目前研究最广泛的免疫调节酶，包括吲哚胺2,3-双加氧酶1、精氨酸酶1、诱导型一氧化氮合酶、甘油醛-3-磷酸脱氢酶和外核苷三磷酸二磷酸水解酶1。提供了它们的分类，以及对这组酶固有的独特特征的分析。并展望了免疫调节酶在医学上应用的新方向。

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Immunoregulatory Enzymes.

Immunoregulatory enzymes, which function both as biological catalysts and regulatory elements, play a crucial role in controlling immune responses. Dysfunction of these proteins can contribute to various pathological conditions, such as the suppression of antitumor immunity or impairment of anti-infectious immune responses. This review discusses the most extensively studied immunoregulatory enzymes, including indoleamine 2,3-dioxygenase 1, arginase 1, inducible nitric oxide synthase, glyceraldehyde-3-phosphate dehydrogenase, and ectonucleoside triphosphate diphosphohydrolase 1. Their classification is provided, along with an analysis of the distinctive characteristics inherent to this group of enzymes. Additionally, new directions for the medical application of immunoregulatory enzymes are explored.

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来源期刊

Acta Naturae 农林科学-林学

CiteScore

3.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Acta Naturae is an international journal on life sciences based in Moscow, Russia. Our goal is to present scientific work and discovery in molecular biology, biochemistry, biomedical disciplines and biotechnology. These fields represent the most important priorities for the research and engineering development both in Russia and worldwide. Acta Naturae is also a periodical for those who are curious in various aspects of biotechnological business, innovations in pharmaceutical areas, intellectual property protection and social consequences of scientific progress. The journal publishes analytical industrial surveys focused on the development of different spheres of modern life science and technology. Being a radically new and totally unique journal in Russia, Acta Naturae is useful to both representatives of fundamental research and experts in applied sciences.