2024年的亮点：超越脂质：apoe4相关阿尔茨海默病的免疫功能障碍

IF 3.2 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2025-04-30 DOI:10.1111/imcb.70025

Isabella McEwan, Shannon Thomson, Jasmeen K Issar, Caitlin A Finney

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引用次数: 0

摘要

在这篇“2024年亮点”系列文章中，我们讨论了我们和其他人的研究结果，即阿尔茨海默病（AD）风险遗传变异载脂蛋白E ε4 （APOE4）与外周免疫失调和慢性炎症有关。我们假设这是通过促炎免疫细胞攻击血脑屏障（BBB）来削弱它，从而导致AD的发展。免疫细胞随后渗透到大脑中，在那里它们与脑细胞相互作用，导致神经炎症、神经变性和AD病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Highlights of 2024: Beyond lipids: immune dysfunction in APOE4-associated Alzheimer's disease.

In this article for the "Highlights of 2024" Series, we discuss findings by our group and others that the Alzheimer's disease (AD) risk genetic variant apolipoprotein E ε4 (APOE4) is associated with peripheral immune dysregulation and chronic inflammation. We hypothesize that this leads to AD development via proinflammatory immune cells attacking the blood-brain barrier (BBB) to weaken it. Immune cells then infiltrate into the brain where they interact with brain cells to drive neuroinflammation, neurodegeneration, and AD pathology.

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.