脉络膜丛体积与多发性硬化症的相关性。

IF 5.9 1区 医学 Q1 NEUROSCIENCES
Britta Krieger, Barbara Bellenberg, Anna Katharina Roenneke, Ruth Schneider, Theodoros Ladopoulos, Zainab Abbas, Rebekka Rust, Tanja Schmitz-Hübsch, Claudia Chien, Ralf Gold, Friedemann Paul, Carsten Lukas
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引用次数: 0

摘要

背景:脉络膜丛(ChP)在多发性硬化症(MS)的炎症过程中起关键作用。复发-缓解型多发性硬化症(RRMS)的ChP增大被认为是疾病活动性的指征,并且与心室周围再髓鞘化失败有关。本横断面研究旨在确定ChP与MS发生的心室周围组织损伤之间的关系,并阐明神经炎症在原发性进行性多发性硬化症(PPMS)中的作用。方法:基于从两个中心获取的结构MRI数据,采用一种新的深度学习分割方法评估ChP体积。共纳入141例RRMS和64例PPMS患者,以及75名健康对照者。此外,计算心室周围带内的T1w/FLAIR比率,以量化微结构组织损伤并评估其与ChP体积的关系。结果:与健康对照相比,RRMS患者的ChP体积显著增加,但PPMS患者没有。与健康对照组相比,多发性硬化症患者显示心室周围梯度的正常白质(NAWM)的T1w/FLAIR比值降低,而PPMS患者侧脑室放射的T1w/FLAIR比值较低。在RRMS患者的心室周围带内,ChP体积与NAWM的T1w/FLAIR比值存在相关性。只有RRMS患者病程越长,ChP体积越大。在RRMS中,ChP体积增大也与皮质体积减小和病变体积增加显著相关。结论:我们的分析证实,ChP在RRMS患者中显著增大,这与脑损伤体积有关,并提示其动态发展,因为它与疾病持续时间有关。神经丛扩大进一步与心室周围脱髓鞘或组织损伤相关,以RRMS的T1w/FLAIR比率评估。此外,我们没有发现PPMS患者的ChP增大,这可能表明在ms进展期炎症过程的参与减少。RRMS中ChP体积增大与皮质萎缩之间的关联突出了靠近CSF的结构的脆弱性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relevance of choroid plexus volumes in multiple sclerosis.

Background: The choroid plexus (ChP) plays a pivotal role in inflammatory processes that occur in multiple sclerosis (MS). The enlargement of the ChP in relapsing-remitting multiple sclerosis (RRMS) is considered to be an indication of disease activity and has been associated with periventricular remyelination failure. This cross-sectional study aimed to identify the relationship between ChP and periventricular tissue damage which occurs in MS, and to elucidate the role of neuroinflammation in primary progressive multiple sclerosis (PPMS).

Methods: ChP volume was assessed by a novel deep learning segmentation method based on structural MRI data acquired from two centers. In total, 141 RRMS and 64 PPMS patients were included, along with 75 healthy control subjects. In addition, T1w/FLAIR ratios were calculated within periventricular bands to quantify microstructural tissue damage and to assess its relationship to ChP volume.

Results: When compared to healthy controls, ChP volumes were significantly increased in RRMS, but not in patients with PPMS. T1w/FLAIR ratios in the normal appearing white matter (NAWM) showing periventricular gradients were decreased in patients with multiple sclerosis when compared to healthy control subjects and lower T1w/FLAIR ratios radiating out from the lateral ventricles were found in patients with PPMS. A relationship between ChP volume and T1w/FLAIR ratio in NAWM was found within the inner periventricular bands in RRMS patients. A longer duration of disease was associated with larger ChP volumes only in RRMS patients. Enlarged ChP volumes were also significantly associated with reduced cortex volumes and increased lesion volumes in RRMS.

Conclusions: Our analysis confirmed that the ChP was significantly enlarged in patients with RRMS, which was related to brain lesion volumes and which suggested a dynamic development as it was associated with disease duration. Plexus enlargement was further associated with periventricular demyelination or tissue damage assessed by T1w/FLAIR ratios in RRMS. Furthermore, we did not find an enlargement of the ChP in patients with PPMS, possibly indicating the reduced involvement of inflammatory processes in the progressive phase of MS. The association between enlarged ChP volumes and cortical atrophy in RRMS highlighted the vulnerability of structures close to the CSF.

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来源期刊
Fluids and Barriers of the CNS
Fluids and Barriers of the CNS Neuroscience-Developmental Neuroscience
CiteScore
10.70
自引率
8.20%
发文量
94
审稿时长
14 weeks
期刊介绍: "Fluids and Barriers of the CNS" is a scholarly open access journal that specializes in the intricate world of the central nervous system's fluids and barriers, which are pivotal for the health and well-being of the human body. This journal is a peer-reviewed platform that welcomes research manuscripts exploring the full spectrum of CNS fluids and barriers, with a particular focus on their roles in both health and disease. At the heart of this journal's interest is the cerebrospinal fluid (CSF), a vital fluid that circulates within the brain and spinal cord, playing a multifaceted role in the normal functioning of the brain and in various neurological conditions. The journal delves into the composition, circulation, and absorption of CSF, as well as its relationship with the parenchymal interstitial fluid and the neurovascular unit at the blood-brain barrier (BBB).
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