人PTPN22催化结构域的1H， 13C和15N骨架共振分配。

IF 0.8 4区生物学 Q4 BIOPHYSICS

Biomolecular NMR Assignments Pub Date : 2025-04-25 DOI:10.1007/s12104-025-10233-6

Bryan T Martin, Michael W Clarkson, Ping Wu, Paola Di Lello

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引用次数: 0

摘要

蛋白酪氨酸磷酸酶非受体22型（PTPN22）是一种酪氨酸-磷酸酶，在免疫细胞中抑制t细胞活化起主要作用。最近的研究表明，下调PTPN22可触发t细胞活化，增强抗肿瘤免疫反应，从而确定PTPN22是癌症免疫学中的潜在药理靶点。在这里，我们报道了人类PTPN22 35.6 kDa催化结构域的1H， 15N和13C骨干共振分配。这项任务将提供一个必要的实验工具来识别和表征潜在的PTPN22抑制剂。

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¹H, ¹³C and ¹⁵N backbone resonance assignment of the catalytic domain of human PTPN22.

Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is a tyrosine-phosphatase that plays a major role in inhibiting T-cell activation in immune cells. Recent studies have revealed that downregulation of PTPN22 triggers T-cell activation and enhances antitumor immune response, thereby identifying PTPN22 as a potential pharmacological target in cancer-immunology.Here we report the ¹H, ¹⁵N and ¹³C backbone resonance assignment for the 35.6 kDa catalytic domain of human PTPN22. This assignment will provide an essential experimental tool to identify and characterize potential PTPN22 inhibitors.

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来源期刊

Biomolecular NMR Assignments 生物-光谱学

CiteScore

1.70

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Biomolecular NMR Assignments provides a forum for publishing sequence-specific resonance assignments for proteins and nucleic acids as Assignment Notes. Chemical shifts for NMR-active nuclei in macromolecules contain detailed information on molecular conformation and properties. Publication of resonance assignments in Biomolecular NMR Assignments ensures that these data are deposited into a public database at BioMagResBank (BMRB; http://www.bmrb.wisc.edu/), where they are available to other researchers. Coverage includes proteins and nucleic acids; Assignment Notes are processed for rapid online publication and are published in biannual online editions in June and December.